ArticleResearch square2021
Functional antibody and T-cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study.
Registry-linked trialAbstract readPreprint
In one paragraph
Article in Research square, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03226886 (TRACERx Renal), which is not on this map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TRACERx Renal (TRAcking Renal Cell Carcinoma Evolution Through Therapy (Rx)) CAPTURE: COVID-19 Antiviral Response in a Pan-tumour Immune Study
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Updated by
Authors and funding
87 authors.
Annika FendlerCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Lewis AuCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Scott T C ShepherdCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Fiona ByrneCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Maddalena CerroneTuberculosis Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Laura Amanda BoosSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Karolina RzeniewiczCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
William GordonCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Ben ShumCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Camille L GerardCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Barry WardCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Wenyi XieCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Andreas M SchmittSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Nalinie Joharatnam-HoganSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Georgina H CornishRetroviral Immunology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Martin PuleResearch Department of Haematology at University College London Cancer Institute, WC1E 6DD, London, UK.
Leila MekkaouiAutolus Limited, The MediaWorks, 191 Wood Lane, London, W12 7F.
Kevin W NgRetroviral Immunology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Eleanor CarlyleSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Kim EdmondsSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Lyra Del RosarioSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Sarah SarkerSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Karla LingardSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Mary MangwendeSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Lucy HoltSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Hamid AhmodSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Richard StoneAutolus Limited, The MediaWorks, 191 Wood Lane, London, W12 7F.
Camila GomesAutolus Limited, The MediaWorks, 191 Wood Lane, London, W12 7F.
Helen R FlynnMass Spectrometry Proteomics Science Technology Platform, The Francis Crick Institute, London, NW1 1AT, UK.
Ana Agua-DoceFlow Cytometry Scientific Technology Platform, The Francis Crick Institute, London, NW1 1AT, UK.
Philip HobsonFlow Cytometry Scientific Technology Platform, The Francis Crick Institute, London, NW1 1AT, UK.
Simon CaidanSafety, Health & Sustainability, The Francis Crick Institute, London, NW1 1AT, UK.
Michael HowellHigh Throughput Screening Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Mary WuHigh Throughput Screening Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Robert GoldstoneAdvanced Sequencing Facility, The Francis Crick Institute, London, NW1 1AT, UK.
Margaret CrawfordAdvanced Sequencing Facility, The Francis Crick Institute, London, NW1 1AT, UK.
Laura CubittAdvanced Sequencing Facility, The Francis Crick Institute, London, NW1 1AT, UK.
Harshil PatelDepartment of Bioinformatics and Biostatistics, The Francis Crick Institute, London, UK.
Mike GavrielidesScientific Computing Scientific Technology Platform, The Francis Crick Institute, London, NW1 1AT, UK.
Emma NyeExperimental Histopathology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Ambrosius P SnijdersMass Spectrometry Proteomics Science Technology Platform, The Francis Crick Institute, London, NW1 1AT, UK.
James I MacRaeMetabolomics Scientific Technology Platform, The Francis Crick Institute, London, NW1 1AT, UK.
Jerome NicodAdvanced Sequencing Facility, The Francis Crick Institute, London, NW1 1AT, UK.
Firza GronthoudDepartment of Pathology, The Royal Marsden NHS Foundation Trust, London, NW1 1AT, UK.
Robyn L SheaDepartment of Pathology, The Royal Marsden NHS Foundation Trust, London, NW1 1AT, UK.
Christina MessiouDepartment of Radiology, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
David CunninghamGastrointestinal Unit, The Royal Marsden NHS Foundation Trust, London and Surrey SM2 5PT.
Ian ChauGastrointestinal Unit, The Royal Marsden NHS Foundation Trust, London and Surrey SM2 5PT.
Naureen StarlingGastrointestinal Unit, The Royal Marsden NHS Foundation Trust, London and Surrey SM2 5PT.
Nicholas TurnerBreast Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Liam WelshNeuro-oncology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Nicholas van AsClinical Oncology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Robin L JonesSarcoma Unit, The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, SW3 6JJ, UK.
Joanne DroneyPalliative Medicine, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Susana BanerjeeGynaecology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Kate C TathamAnaesthetics, Perioperative Medicine and Pain Department, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Shaman JhanjiAnaesthetics, Perioperative Medicine and Pain Department, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Mary O'BrienLung Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Olivia CurtisLung Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Kevin HarringtonHead and Neck, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Shreerang BhideHead and Neck, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Jessica BazinHaemato-oncology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Anna RobinsonHaemato-oncology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Clemency StephensonHaemato-oncology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Tim SlatterySkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Yasir KhanSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Zayd TippuSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Isla LeslieSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Spyridon GennatasAcute Oncology Service, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Alicia OkinesBreast Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Alison ReidUro-oncology unit, The Royal Marsden NHS Foundation Trust, Surrey, SM2 5PT.
Kate YoungSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Andrew J S FurnessSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Lisa PickeringSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Sonia GandhiNeurodegeneration Biology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Steve GamblinStructural Biology of Disease Processes Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Charles SwantonCancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Emma NicholsonHaemato-oncology Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Sacheen KumarGastrointestinal Unit, The Royal Marsden NHS Foundation Trust, London and Surrey SM2 5PT.
Nadia YousafLung Unit, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Katalin A WilkinsonTuberculosis Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Anthony SwerdlowDivision of Genetics and Epidemiology and Division of Breast Cancer Research, The Institute of Cancer Research, London, SW7 3RP, UK.
Ruth HarveyWorldwide Influenza Centre, The Francis Crick Institute, London, NW1 1AT, UK.
George KassiotisRetroviral Immunology Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
James LarkinSkin and Renal Units, The Royal Marsden NHS Foundation Trust, London, SW3 6JJ, UK.
Robert J WilkinsonTuberculosis Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Samra TurajlicCancer Dynamics Laboratory, The Francis Crick Institute, London, NW1 1AT, UK.
Funding
Deciphering Clonal Evolution in Hereditary Renal Cell CarcinomasU01CA247439 · NCI · FRANCIS CRICK INSTITUTE, LTD · PI TURAJLIC, SAMRA · 2020 to 2024
$1.1MNCI NIH HHS U01 CA247439Wellcome Trust FC001002Wellcome Trust FC001030Wellcome Trust FC001078Wellcome Trust FC001099Wellcome Trust FC001169Wellcome Trust FC001218Wellcome Trust FC001988
Abstract
Patients with cancer have higher COVID-19 morbidity and mortality. Here we present the prospective CAPTURE study (NCT03226886) integrating longitudinal immune profiling with clinical annotation. Of 357 patients with cancer, 118 were SARS-CoV-2-positive, 94 were symptomatic and 2 patients died of COVID-19. In this cohort, 83% patients had S1-reactive antibodies, 82% had neutralizing antibodies against WT, whereas neutralizing antibody titers (NAbT) against the Alpha, Beta, and Delta variants were substantially reduced. Whereas S1-reactive antibody levels decreased in 13% of patients, NAbT remained stable up to 329 days. Patients also had detectable SARS-CoV-2-specific T cells and CD4+ responses correlating with S1-reactive antibody levels, although patients with hematological malignancies had impaired immune responses that were disease and treatment-specific, but presented compensatory cellular responses, further supported by clinical. Overall, these findings advance the understanding of the nature and duration of immune response to SARS-CoV-2 in patients with cancer.
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT03226886ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.