Evidence map›Paper›PMID 34580605›Full record

ArticleJournal of nanostructure in chemistry2022

Calcium-based nanomaterials and their interrelation with chitosan: optimization for pCRISPR delivery.

Navid Rabiee, Mojtaba Bagherzadeh, Amir Mohammad Ghadiri, Mahsa Kiani, Sepideh Ahmadi, Vahid Jajarmi, Yousef Fatahi, Abdullah Aldhaher, Mohammadreza Tahriri, Thomas J Webster and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanostructure in chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 40 citations in OpenAlex.

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  17. Metal-Organic Frameworks (MOFs) for Cancer Therapy.Materials (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Navid RabieeDepartment of Chemistry, Sharif University of Technology, Tehran, Iran.
Mojtaba BagherzadehDepartment of Chemistry, Sharif University of Technology, Tehran, Iran.
Amir Mohammad GhadiriDepartment of Chemistry, Sharif University of Technology, Tehran, Iran.
Mahsa KianiDepartment of Chemistry, Sharif University of Technology, Tehran, Iran.
Sepideh AhmadiStudent Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Vahid JajarmiDepartment of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Yousef FatahiDepartment of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14155-6451 Iran.
Abdullah AldhaherDepartment of Chemistry, Sharif University of Technology, Tehran, Iran.
Mohammadreza TahririDepartment of Engineering, Norfolk State University, Norfolk, VA 23504 USA.
Thomas J WebsterDepartment of Chemical Engineering, Northeastern University, Boston, MA 02115 USA.
Ebrahim MostafaviDepartment of Chemical Engineering, Northeastern University, Boston, MA 02115 USA.ORCID 0000-0003-3958-5002
Sharif University of Technology · IRNortheastern University · USShahid Beheshti University of Medical Sciences · IRNorfolk State University · USUniversal Scientific Education and Research Network · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There have been numerous advancements in the early diagnosis, detection, and treatment of genetic diseases. In this regard, CRISPR technology is promising to treat some types of genetic issues. In this study, the relationship between calcium (due to its considerable physicochemical properties) and chitosan (as a natural linear polysaccharide) was investigated and optimized for pCRISPR delivery. To achieve this, different forms of calcium, such as calcium nanoparticles (CaNPs), calcium phosphate (CaP), a binary blend of calcium and chitosan including CaNPs/Chitosan and CaP/Chitosan, as well as their tertiary blend including CaNPs-CaP/Chitosan, were prepared via both routine and green procedures using Supplementary Information: The online version contains supplementary material available at 10.1007/s40097-021-00446-1.

Indexed as

Calcium-based non-viral vectorChitosan-based nanomaterialsGene deliverypCRISPR

Identifiers

PMID34580605
PMCPMC8457547
OpenAlexW3201255270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.