Evidence map›Paper›PMID 34580428›Full record

ArticleMucosal immunology2022

Early life exposure to house dust mite allergen prevents experimental allergic asthma requiring mitochondrial H

Huijuan Yuan, Jie Chen, Sanmei Hu, Timothy B Oriss, Sagar Laxman Kale, Sudipta Das, Seyed M Nouraie, Prabir Ray, Anuradha Ray

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Multifaceted roles of mitochondria in asthma.Cell biology and toxicology · 2024
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Huijuan YuanDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jie ChenDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Sanmei HuDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Timothy B OrissDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Sagar Laxman KaleDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Sudipta DasDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Seyed M NouraieDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Prabir RayDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Anuradha RayDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. raya@pitt.edu.
University of Pittsburgh · US

Funding

Regulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2014 to 2023
$21.3M
Project 2 Impact of Innate and Adaptive Immunity At the Airway Epithelium in Severe AsthmaP01AI106684 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Anuradha Ray · 2015 to 2026
$18.9M
MECHANISMS OF ANTIGEN INDUCED TOLERANCE IN THE LUNGR01AI048927 · NIAID · YALE UNIVERSITY · PI RAY, ANURADHA · 2001 to 2020
$8.0M
Understanding Severe Asthma Using an Experimental ModelR01HL113956 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, ANURADHA, RAY, PRABIR · 2013 to 2021
$3.5M
NHLBI NIH HHS P01 HL114453NHLBI NIH HHS R01 HL113956NIAID NIH HHS P01 AI106684NIAID NIH HHS R01 AI048927
6 · The paper itself

Abstract

Immune tolerance to allergens in early-life decreases the risk for asthma in later life. Here we show establishment of stable airway tolerance to the allergen, house dust mite (HDM), by exposing newborn mice repeatedly to a low dose of the allergen. Lung dendritic cells (DCs) from tolerized mice induced a low Th2 response in vitro mirroring impact of tolerance in vivo. In line with our previous finding of increased mitochondrial H

Indexed as

AllergensAnimalsAnimals, NewbornAntigens, DermatophagoidesAsthmaDendritic CellsDisease Models, AnimalHumansHydrogen PeroxideHypersensitivityImmune ToleranceLungMiceMice, Inbred C57BLMice, TransgenicMitochondriaAllergensAntigens, DermatophagoidesHydrogen Peroxide

Identifiers

PMID34580428
PMCPMC8738138
OpenAlexW3204539347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.