Evidence map›Paper›PMID 34580414›Full record

ArticleCommunications biology2021

Direct tissue-sensing reprograms TLR4

Daniela Amaral-Silva, Rute Gonçalves, Rita C Torrão, Rita Torres, Sandra Falcão, Maria João Gonçalves, Maria Paula Araújo, Maria José Martins, Carina Lopes, Agna Neto and 14 more

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Impact ofInternational journal of molecular sciences · 2026
    Article
  2. Article
  3. How does oxytocin modulate human behavior?Molecular psychiatry · 2025
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 2 institutions in 2 countries.

Daniela Amaral-SilvaHuman Immunobiology and Pathogenesis Group, Lisboa, Portugal.ORCID 0000-0003-4468-9703
Rute GonçalvesHuman Immunobiology and Pathogenesis Group, Lisboa, Portugal.
Rita C TorrãoHuman Immunobiology and Pathogenesis Group, Lisboa, Portugal.
Rita TorresiNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon, Lisboa, Portugal.
Sandra FalcãoiNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon, Lisboa, Portugal.
Maria João GonçalvesHospital Egas Moniz, Rua da Junqueira n° 126, Lisboa, Portugal.
Maria Paula AraújoHospital Egas Moniz, Rua da Junqueira n° 126, Lisboa, Portugal.
Maria José MartinsHospital Egas Moniz, Rua da Junqueira n° 126, Lisboa, Portugal.
Carina LopesHospital Egas Moniz, Rua da Junqueira n° 126, Lisboa, Portugal.
Agna NetoiNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon, Lisboa, Portugal.
José MaronaHospital Egas Moniz, Rua da Junqueira n° 126, Lisboa, Portugal.
Tiago CostaHospital Egas Moniz, Rua da Junqueira n° 126, Lisboa, Portugal.
Walter CastelãoHospital Egas Moniz, Rua da Junqueira n° 126, Lisboa, Portugal.
Ana Bento SilvaHospital Egas Moniz, Rua da Junqueira n° 126, Lisboa, Portugal.ORCID 0000-0002-8590-8119
Inês SilvaHospital Egas Moniz, Rua da Junqueira n° 126, Lisboa, Portugal.
Maria Helena LourençoHospital Egas Moniz, Rua da Junqueira n° 126, Lisboa, Portugal.
Margarida MateusHospital Egas Moniz, Rua da Junqueira n° 126, Lisboa, Portugal.
Nuno Pina GonçalvesiNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon, Lisboa, Portugal.
Santiago ManicaiNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon, Lisboa, Portugal.
Manuela CostaHospital Egas Moniz, Rua da Junqueira n° 126, Lisboa, Portugal.
Fernando M Pimentel-SantosiNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon, Lisboa, Portugal.
Ana Filipa MourãoiNOVA4Health | CEDOC, NOVA Medical School | Faculdade de Ciências Médicas, NOVA University of Lisbon, Lisboa, Portugal.
Jaime C BrancoHospital Egas Moniz, Rua da Junqueira n° 126, Lisboa, Portugal.
Helena SoaresHuman Immunobiology and Pathogenesis Group, Lisboa, Portugal. helena.soares@nms.unl.pt.ORCID 0000-0002-5881-3843
Hospital de Egas Moniz · PTUniversity of Lisbon · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD4

Indexed as

AgedArthritis, RheumatoidFemaleHumansMaleMiddle AgedSynovial FluidT-LymphocytesToll-Like Receptor 4TLR4 protein, humanToll-Like Receptor 4

Identifiers

PMID34580414
PMCPMC8476501
OpenAlexW3204186027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.