ArticleScientific reports2021
Prevalence of peripheral neuropathy defined by monofilament insensitivity in middle-aged and older adults in two US cohorts.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Meta-analysis of the normal diffusion tensor imaging values of the peripheral nerves in the upper limb.Scientific reports · 2023Pooled it
- Trial
- Combination therapy with ruxolitinib and pegylated interferon alfa-2a in newly diagnosed patients with polycythemia vera.Blood advances · 2024Trial
- Longitudinal assessment of metabolic and neurological decline in peripheral polyneuropathy over ten years.Future science OA · 2026Article
- Reversible, Sexually Dimorphic Sympathetic Aging: Distal Axon Withdrawal Shaped by Prepubertal Gonadal Influences.bioRxiv : the preprint server for biology · 2026Article
- Screening for Diabetic Peripheral Neuropathy: Subjective Versus Objective Measures.The international journal of lower extremity wounds · 2026Article
- PTEN Regulates Microtubule Polymerization via mTORC2, But Not mTORC1, in Peripheral Sensory Neurons.eNeuro · 2026Article
- Empowering community pharmacists: expert consensus guidance for the effective management of peripheral neuropathy with neurotropic B vitamins.Journal of pharmaceutical health care and sciences · 2026Article
- National mortality trends in polyneuropathies and other disorders of the peripheral nervous system in the United States, 1999-2023: a CDC WONDER database analysis.BMC neurology · 2026Article
- Targeting risk factors and strategies for prevention of peripheral neuropathy: focus on B-vitamin deficiencies and metabolic diseases.Neurological research and practice · 2026Review
- A New Simple SCreening Tool for Painful Diabetic Neuropathy (ACT) in Ecuador.Journal of the peripheral nervous system : JPNS · 2026Observational
- Symptom burden among long-term survivors of young adult cancer: a report from the Project Milestones cohort.Journal of cancer survivorship : research and practice · 2026Article
- Dietary folic acid prevents peripheral neuropathy in mouse models of neural tube defects and type 2 diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Prevalence and determinants of peripheral neuropathy among older Malaysians: Insights from a community-based cross-sectional study.Journal of family medicine and primary care · 2026Article
- Prevalence of PD-1 Inhibitor-Associated Peripheral Neuropathy: A Retrospective Cohort Study.Life (Basel, Switzerland) · 2025Article
- The Associations of Circulating Sphingolipid Levels with Future Loss of Vibration and Light Pressure Sensation in the Lower Limb.Biomedicines · 2025Article
- Prevalence of Peripheral Neuropathy Among Very Old Adults: Evidence From the Michigan Neuropathy Screening Instrument.Journal of the American Geriatrics Society · 2025Article
- Estimating the annual cost burden of diabetic peripheral neuropathy in the United States.Endocrine · 2025Article
- Racial and Ethnic Differences in Peripheral Neuropathy Risk Factors Among United States Adults.Neurology · 2025Article
- Review of the contribution of clinical and genetic factors to the racial disparity in taxane-induced peripheral neuropathy.Critical reviews in oncology/hematology · 2025Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Peripheral neuropathy is associated with substantial morbidity, but risk factors other than diabetes are largely uncharacterized. The aim of this study was to describe the prevalence and risk factors for peripheral neuropathy in adults with and without diabetes from two different population-based studies in the US. We performed a cross-sectional analysis of 5200 black and white participants from NHANES (1999-2004, age 40-85 years) and 3362 black and white participants from the ARIC Study (2016-2017, age 70-89 years) who underwent monofilament testing for peripheral neuropathy using a shared protocol. We used logistic regression to quantify age, sex, and race-adjusted risk factor associations for peripheral neuropathy among middle-aged (40-69 years) and older (≥ 70 years) adults. The age, sex, and race-adjusted prevalence of peripheral neuropathy (decreased sensation on monofilament testing) was 10.4% for middle-aged adults in NHANES, 26.8% for older adults in NHANES, and 39.2% for older adults in ARIC. Diabetes was an important risk factor, but more strongly associated with peripheral neuropathy in middle-aged (OR ~ 5 for long-standing diabetes) compared to older adults (ORs ~ 1.5-2). Male sex (ORs ~ 2), black race (ORs ~ 1.3-1.5), and greater height (ORs ~ 1.5-3) were robust risk factors for peripheral neuropathy. Other risk factors included body mass index, education, and peripheral artery disease. The burden of peripheral neuropathy defined by abnormal monofilament testing among older adults is substantial, even among adults without diabetes. Studies are needed to understand the etiology and prognosis of peripheral neuropathy in the absence of diabetes.
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