ArticleScientific reports2021
Importance of medication adherence in treatment needed diabetic retinopathy.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Patient and Physician Perspectives on Oral Treatment in Ophthalmology.Ophthalmology and therapy · 2026Article
- Advancing Treatment of Degenerative Eye Diseases at the Nanoscale.Smart medicine · 2026Review
- Associations Between Initial Glycated Hemoglobin at Diabetes Diagnosis, Longitudinal Changes and Medication Effects, and the Severity and Progression of Sight-Threatening Diabetic Retinopathy.The Kaohsiung journal of medical sciences · 2026Article
- Prevalence and factors associated with comorbidities in Iranian patients with type 2 diabetes: A national study.PloS one · 2026Article
- Article
- Bisphosphonate compliance in Japan from the perspective of product, formulation, and patient characteristics: analysis of medical insurance claim data.Journal of pharmaceutical health care and sciences · 2025Article
- Medication Adherence Interventions Among People Living with Diabetes: A Systematic Review.Patient preference and adherence · 2025Review
- Diabetic macular edema (DME): dissecting pathogenesis, prognostication, diagnostic modalities along with current and futuristic therapeutic insights.International journal of retina and vitreous · 2024Review
- Disability-related disparities in health outcomes among newly diagnosed diabetic patients: A retrospective cohort.BMC public health · 2024Article
- A multi-step approach to develop a "storytelling" intervention to improve patient gout knowledge and improve outpatient follow-up.Contemporary clinical trials communications · 2023Article
- REal-world treatment outcomes after delayed intRavitreal therapy in center-involving diabetic macular edema - RETORT study.International journal of retina and vitreous · 2023Article
- People with diabetes adherence to drug, dietary, and lifestyle changes in Erbil city, Iraq.BMC endocrine disorders · 2022Article
- Transition from Laser to Intravitreal Injections for Diabetic Retinopathy: Hospital Utilization and Costs from an Extended Healthcare Perspective.International journal of environmental research and public health · 2022Article
- Adherence to Medication in Older Adults with Type 2 Diabetes Living in Lubuskie Voivodeship in Poland: Association with Frailty Syndrome.Journal of clinical medicine · 2022Article
- Primary Localized Gastrointestinal Stromal Tumors: Medication Adherence and Prognosis According to Gender.Patient preference and adherence · 2022Article
- Validation of Diabetes Knowledge Questionnaire (DKQ) in the Taiwanese Population - Concurrent Validity with Diabetes-Specific Quality of Life Questionnaire Module.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We aim to investigate the role of medication adherence history in treatment needed diabetic retinopathy (TNDR). We conducted a retrospective nested case-control study using 3 population-based databases in Taiwan. The major one was the 2-million-sample longitudinal health and welfare population-based database from 1997 to 2017, a nationally representative random sample of National Health Insurance Administration enrolled beneficiaries in 2010 (LHID2010). The national death registry and national cancer registry were also checked to verify the information. The outcome was defined as the TNDR. The Medication possession ratio (MPR) was defined as the ratio of total days of diabetes mellitus (DM) medication supply divided by total observation days. MPR ≥ 80% was proposed as good medication adherence. The association of MPR and the TNDR was analyzed. Other potential confounders and MPR ratio were also evaluated. A total of (n = 44,628) patients were enrolled. Younger aged, male sex and patients with less chronic illness complexity or less diabetes complication severity tend to have poorer medication adherence. Those with severe comorbidity or participating pay-for-performance program (P4P) revealed better adherence. No matter what the characteristics are, patients with good MPR showed a significantly lower likelihood of leading to TNDR after adjustment with other factors. The protection effect was consistent for up to 5 years. Good medication adherence significantly prevents treatment needed diabetic retinopathy. Hence, it is important to promote DM medication adherence to prevent risks of diabetic retinopathy progression, especially those who opt to have low medication adherence.
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