ArticleScientific reports2021
Differentiation of uterine low-grade endometrial stromal sarcoma from rare leiomyoma variants by magnetic resonance imaging.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- MRI for diagnosing uterine sarcoma: a systematic review and meta-analysis.Japanese journal of radiology · 2026Pooled it
- European Society of Urogenital Radiology (ESUR) guidelines on MR imaging prior to fertility-sparing treatments in patients with cervical, endometrial, and ovarian cancers.European radiology · 2025Guideline
- Development and External Testing of an Interpretable MRI-Based Machine Learning Model for Differentiating Endometrial Stromal Sarcoma from Cellular Leiomyoma.Journal of imaging informatics in medicine · 2026Article
- MRI insights into endometrial stromal tumors.Insights into imaging · 2026Article
- A Rare Case of Low-Grade Endometrial Stromal Sarcoma: Diagnostic Insights and Therapeutic Considerations.Cureus · 2025Article
- Article
- Multimodal imaging features of high-grade endometrial stromal sarcoma with pulmonary and nodal metastases: a case report and literature review.Frontiers in medicine · 2025Article
- Low-Grade Endometrial Stromal Sarcoma: A Case Report of a Rare Uterine Malignancy Mimicking Degenerative Uterine Leiomyoma in a Nulliparous Woman.Diagnostics (Basel, Switzerland) · 2024Article
- Article
- Smooth muscle tumours of the uterus: MR imaging malignant predictive features-a 12-year analysis in a referral hospital in Portugal.Archives of gynecology and obstetrics · 2024Article
- A case of low-grade endometrial stromal sarcoma presented as an intramyometrial mass mimicking uterine leiomyoma on MRI.BJR case reports · 2024Article
- Low grade endometrial stromal sarcoma in pregnancy: A case in support of safe abortion access.Gynecologic oncology reports · 2023Article
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13 authors.
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Abstract
The purpose of this study is to evaluate utility of MRI in differentiation of uterine low-grade endometrial stromal sarcoma (LGESS) from rare leiomyoma variants. This multi-center retrospective study included consecutive 25 patients with uterine LGESS and 42 patients with rare leiomyoma variants who had pretreatment MRI. Two radiologists (R1/R2) independently evaluated MRI features, which were analyzed statistically using Fisher's exact test or Student's t-test. Subsequently, using a five-point Likert scale, the two radiologists evaluated the diagnostic performance of a pre-defined MRI system using features reported as characteristics of LGESS in previous case series: uterine tumor with high signal intensity (SI) on diffusion-weighted images and with either worm-like nodular extension, intra-tumoral low SI bands, or low SI rim on T2-weighted images. Area under the receiver operating characteristic curve (AUC), sensitivity, and specificity of the two readers' Likert scales were analyzed. Intra-tumoral low SI bands (p < 0.001), cystic/necrotic change (p ≤ 0.02), absence of speckled appearance (p < 0.001) on T2-weighted images, and a low apparent diffusion coefficient value (p ≤ 0.02) were significantly associated with LGESS. The pre-defined MRI system showed very good diagnostic performance: AUC 0.86/0.89, sensitivity 0.95/0.95, and specificity 0.67/0.69 for R1/R2. MRI can be useful to differentiate uterine LGESS from rare leiomyoma variants.
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