Evidence map›Paper›PMID 34580283›Full record

ArticleCell death & disease2021

METTL14 aggravates podocyte injury and glomerulopathy progression through N

Zhihui Lu, Hong Liu, Nana Song, Yiran Liang, Jiaming Zhu, Jing Chen, Yichun Ning, Jiachang Hu, Yi Fang, Jie Teng and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Mettl3-Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  17. Decoding mJournal of translational medicine · 2025
    Review
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  20. m6A demethylase Fto inhibited macrophage activation and glycolysis in diabetic nephropathy via m6A/Npas2/Hif-1α axis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Zhihui Lu *Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Hong Liu *Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Nana SongDivision of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Yiran LiangDivision of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Jiaming ZhuDivision of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Jing ChenDivision of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Yichun NingDivision of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Jiachang HuDivision of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Yi FangDivision of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Jie TengDivision of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Jianzhou ZouDivision of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, PR China.
Yan DaiDivision of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, PR China. dai.yan1@zs-hospital.sh.cn.ORCID 0000-0001-5890-8087
Xiaoqiang DingDivision of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, PR China. dingxiaoqiang1965@126.com.ORCID 0000-0001-7620-1886
Fudan University · CNShanghai Medical College of Fudan University · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 8170063National Natural Science Foundation of China (National Science Foundation of China) 82070710National Natural Science Foundation of China (National Science Foundation of China) 91849123
6 · The paper itself

Abstract

Podocytes are known to play a determining role in the progression of proteinuric kidney disease. N

Indexed as

Disease ProgressionDown-RegulationAdenosineAnimalsApoptosisAutophagyCytoprotectionDiabetic NephropathiesDoxorubicinGene SilencingGlycation End Products, AdvancedInflammationMaleMethyltransferasesMiceMice, Inbred C57BLAdenosineDoxorubicinGlycation End Products, AdvancedMethyltransferasesMettl14 protein, mouseN-methyladenosineRNA, MessengerSirtuin 1

Identifiers

PMID34580283
PMCPMC8476597
OpenAlexW3201757416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.