Evidence map›Paper›PMID 34580275›Full record

ArticleCell death & disease2021

Specific deletion of protein phosphatase 6 catalytic subunit in Sertoli cells leads to disruption of spermatogenesis.

Wen-Long Lei, Yuan-Yuan Li, Tie-Gang Meng, Yan Ning, Si-Min Sun, Chun-Hui Zhang, Yaoting Gui, Zhen-Bo Wang, Wei-Ping Qian, Qing-Yuan Sun

Open access · goldAbstract read
In one paragraph

Article in Cell death & disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. ProPept-MT: A Multi-Task Learning Model for Peptide Feature Prediction.International journal of molecular sciences · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Wen-Long LeiDepartment of Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen, 518036, China.ORCID 0000-0003-0562-5125
Yuan-Yuan LiState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Tie-Gang MengState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.ORCID 0000-0001-8069-0256
Yan NingState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Si-Min SunState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Chun-Hui ZhangDepartment of Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Yaoting GuiGuangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, 518036, China.
Zhen-Bo WangState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China. wangzb@ioz.ac.cn.ORCID 0000-0001-5013-251X
Wei-Ping QianDepartment of Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen, 518036, China. qianweipingsz@126.com.ORCID 0000-0002-6868-0861
Qing-Yuan SunFertility Preservation Lab, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China. sunqy@gd2h.org.cn.ORCID 0000-0002-0148-2414
Chinese Academy of Sciences · CNPeking University Shenzhen Hospital · CNGuangdong Provincial Hospital of Traditional Chinese Medicine · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31530049
6 · The paper itself

Abstract

Protein phosphatase 6 (PP6) is a member of the PP2A-like subfamily, which plays significant roles in numerous fundamental biological activities. We found that PPP6C plays important roles in male germ cells recently. Spermatogenesis is supported by the Sertoli cells in the seminiferous epithelium. In this study, we crossed Ppp6c

Indexed as

Catalytic DomainGene DeletionSpermatogenesisAnimalsApoptosisbeta CateninEpididymisExonsInfertility, MaleIntegrasesMaleMiceMice, Inbred C57BLMice, KnockoutPhosphoprotein PhosphatasesPhosphoproteinsbeta CateninCre recombinaseIntegrasesPhosphoprotein PhosphatasesPhosphoproteinsprotein phosphatase 6Proteome

Identifiers

PMID34580275
PMCPMC8476514
OpenAlexW3201800514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.