Evidence map›Paper›PMID 34580177›Full record

ArticleLife science alliance2021

MKP-1 modulates ubiquitination/phosphorylation of TLR signaling.

Jaya Talreja, Christian Bauerfeld, Xiantao Wang, Markus Hafner, Yusen Liu, Lobelia Samavati

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Jaya TalrejaDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, MI, USA.
Christian BauerfeldDepartment of Pediatrics, Division of Critical Care, Central Michigan University, Mount Pleasant, MI, USA.
Xiantao WangLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD, USA.
Markus HafnerLaboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD, USA.
Yusen LiuCenter for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.ORCID 0000-0002-0994-0109
Lobelia SamavatiDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine and Detroit Medical Center, Detroit, MI, USA ay6003@wayne.edu.ORCID 0000-0002-3327-2585
National Institutes of Health · USWayne State University · USCentral Michigan University · USNationwide Children's Hospital · US

Funding

Regulation and Function of Mkp-1 During Sepsis.R01AI124029 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI LIU, YUSEN · 2017 to 2021
$1.9M
Role and Regulation of MKP-1 in SarcoidosisR01HL113508 · NHLBI · WAYNE STATE UNIVERSITY · PI SAMAVATI, LOBELIA · 2013 to 2017
$1.9M
A novel T7 phage display technology to detect sarcoidosis specific antigensR01HL150474 · NHLBI · WAYNE STATE UNIVERSITY · PI SAMAVATI, LOBELIA · 2020 to 2023
$1.8M
Mkp-1 suppresses immune checkpoint protein PD-L1 to prevent sepsis-associated immune dysfunction and mortalityR21AI142885 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI LIU, YUSEN · 2019 to 2020
$418k
NHLBI NIH HHS R01 HL113508NHLBI NIH HHS R01 HL150474NIAID NIH HHS R01 AI124029NIAID NIH HHS R21 AI142885
6 · The paper itself

Abstract

Ubiquitination and phosphorylation are reversible posttranslational protein modifications regulating physiological and pathological processes. MAPK phosphatase (MKP)-1 regulates innate and adaptive immunity. The multifaceted roles of MKP-1 were attributed to dephosphorylation of p38 and JNK MAPKs. We show that the lack of MKP-1 modulates the landscape of ubiquitin ligases and deubiquitinase enzymes (DUBs). MKP-1

Indexed as

AminopyridinesAnimalsCells, CulturedDual Specificity Phosphatase 1Gene Knockout TechniquesInterleukin-1betaLipopolysaccharidesMacrophagesMAP Kinase Signaling SystemMiceMice, Inbred C57BLMice, KnockoutPhosphorylationThiocyanatesTNF Receptor-Associated Factor 6Toll-Like Receptors2,6-diaminopyridine-3,5-bis(thiocyanate)AminopyridinesDual Specificity Phosphatase 1Dusp1 protein, mouseIL1B protein, mouseInterleukin-1betaLipopolysaccharidesThiocyanatesTNF Receptor-Associated Factor 6Toll-Like ReceptorsTRAF6 protein, mouseUbiquitinUbiquitin-Specific ProteasesUsp13 protein, mouse

Identifiers

PMID34580177
PMCPMC8500224
OpenAlexW3203312792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.