ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Does Hemispheric Asymmetry Reduction in Older Adults in Motor Cortex Reflect Compensation?
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Translation of task-evoked negative BOLD response into aging and Alzheimer's disease: a systematic review of the current literature.Journal of translational medicine · 2025Pooled it
- Oscillatory dynamics of motor learning across adulthood life span: a systematic review.Frontiers in aging neuroscience · 2025Pooled it
- Alpha-Band EEG Modulation as a Potential Aged-Related Biomarker for Biofeedback-Driven Motor-Cognitive Adaptability.Sensors (Basel, Switzerland) · 2026Article
- The effects of handedness and age on hand role selection in bimanual tasks.Experimental brain research · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Cardiorespiratory fitness is differentially associated with motor cortex laterality in middle-aged and older adults.Scientific reports · 2026Article
- Neural Compensation in the Medial Prefrontal Cortex Preserves Self-Prioritization in Aging: A Computational Approach.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Exploring gait automaticity and prefrontal brain activity during single and dual-task walking in aging and Parkinson's disease.Journal of neuroengineering and rehabilitation · 2026Article
- Dynamic functional reorganization in post-stroke aphasia: a state-of-the-art fMRI review from disease evolution to intervention.Frontiers in neuroscience · 2026Review
- Can aerobic exercise really improve factors related to decision-making capacity in aging? What has been measured, what has been assumed, and what needs to change.Frontiers in sports and active living · 2026Review
- Changing cognitive chimera states in human brain networks with age: Variations in cognitive integration and segregation.PLoS computational biology · 2025Article
- Article
- Rhythmic auditory cues improve gait asymmetry during unobstructed walking in people with Parkinson's disease but have no effect on obstacle avoidance - AsymmGait-Parkinson study.Frontiers in aging neuroscience · 2025Article
- Elevated Activity in Left Homologous Music Circuits Is Inhibitory for Music Perception but Mediated by Structure-Function Coupling.CNS neuroscience & therapeutics · 2024Article
- Evaluating Models of the Ageing BOLD Response.Human brain mapping · 2024Article
- Older adults preserve audiovisual integration through enhanced cortical activations, not by recruiting new regions.PLoS biology · 2024Article
- Temporal localization of upper extremity bilateral synergistic coordination using wearable accelerometers.PeerJ · 2024Article
- Cerebral hyperactivation across the Alzheimer's disease pathological cascade.Brain communications · 2024Review
- Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults.iScience · 2023Article
- Cross-hemispheric recruitment during action planning with increasing task demand.Scientific reports · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Older adults tend to display greater brain activation in the nondominant hemisphere during even basic sensorimotor responses. It is debated whether this hemispheric asymmetry reduction in older adults (HAROLD) reflects a compensatory mechanism. Across two independent fMRI experiments involving adult life span human samples (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.