ArticleMolecular pharmacology2021
Unique Positive Cooperativity Between the
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Molecular pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Biased signaling of β2-adrenergic receptor in physiological and pathological states.Cellular & molecular biology letters · 2026Review
- Biased Agonism at β-Adrenoceptor Subtypes: A Drug Development Perspective.Handbook of experimental pharmacology · 2026Review
- Optimization and Validation of an HPLC Method for the Analysis of Carvedilol and Impurities.ACS omega · 2025Article
- Atenolol, alone or in combination with PTH, has a modest effect on bone in female C57BL/6J mice.JBMR plus · 2025Article
- MDSC checkpoint blockade therapy: a new breakthrough point overcoming immunosuppression in cancer immunotherapy.Cancer gene therapy · 2025Review
- β-adrenergic receptor signaling mediated by β-arrestins and its potential role in heart failure.Current opinion in physiology · 2024Article
- Adrenoceptors: Receptors, Ligands and Their Clinical Uses, Molecular Pharmacology and Assays.Handbook of experimental pharmacology · 2024Review
- How carvedilol does not activate βNature communications · 2023Article
- Reply to: How carvedilol does not activate βNature communications · 2023Article
- Article
- Pathophysiology and pharmacology of G protein-coupled receptors in the heart.Cardiovascular research · 2023Review
- β-arrestin1 regulates astrocytic reactivity via Drp1-dependent mitochondrial fission: implications in postoperative delirium.Journal of neuroinflammation · 2023Article
- Allosteric Regulation of G-Protein-Coupled Receptors: From Diversity of Molecular Mechanisms to Multiple Allosteric Sites and Their Ligands.International journal of molecular sciences · 2023Review
- Non-canonical Golgi-compartmentalized Gβγ signaling: mechanisms, functions, and therapeutic targets.Trends in pharmacological sciences · 2023Review
- In silico identification of a βProceedings of the National Academy of Sciences of the United States of America · 2022Article
- How Carvedilol activates βNature communications · 2022Article
- G protein-coupled receptor signaling: transducers and effectors.American journal of physiology. Cell physiology · 2022Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 4 institutions in 1 country.
Biswaranjan PaniDepartment of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.).
Seungkirl AhnDepartment of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.).
Paula K RambaratDepartment of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.).
Shashank VegeDepartment of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.).
Alem W KahsaiDepartment of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.).
Andrew LiuDepartment of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.).
Bruno N ValanDepartment of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.).
Dean P StausDepartment of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.).
Tommaso CostaDepartment of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.).
Robert J LefkowitzDepartment of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.) lefko001@receptor-biol.duke.edu.
Duke University Hospital · USDuke Medical Center · USHoward Hughes Medical Institute · USMassachusetts General Hospital · US
Funding
Molecular Regulation of Cardiovascular 7 TM ReceptorsR01HL016037 · NHLBI · DUKE UNIVERSITY · PI ROBERT J LEFKOWITZ · 1985 to 2026
$14.5MHoward Hughes Medical InstituteNHLBI NIH HHS R01 HL016037
Abstract
Among
Indexed as
Receptors, Adrenergic, beta-2Adrenergic beta-AntagonistsAllosteric RegulationAnimalsbeta-ArrestinsCarvedilolDose-Response Relationship, DrugHEK293 CellsHumansSf9 CellsAdrenergic beta-Antagonistsbeta-ArrestinsCarvedilolReceptors, Adrenergic, beta-2
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.