ArticleeNeuro
Characterization of the Brain Functional Architecture of Psychostimulant Withdrawal Using Single-Cell Whole-Brain Imaging.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 34 citations in OpenAlex.
- GABAergic neurons in the ventrolateral periaqueductal gray mediate fentanyl withdrawal and self-administration in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Multi-metric resting-state fMRI reveals brain network abnormalities underlying cognitive impairment in male patients during methamphetamine abstinence.BMC psychiatry · 2026Article
- Postpartum adversity in rats creates a hypervigilant maternal state through selective salience-circuit recruitment.Neurobiology of stress · 2026Article
- Disrupted theta synchronization and synaptic connectivity in the visual cortex of Fmr1 KO mice.Nature communications · 2025Article
- Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression.Nature communications · 2025Article
- ClearFinder: a Python GUI for annotating cells in cleared mouse brain.BMC bioinformatics · 2025Article
- Nicotine and neuronal nicotinic acetylcholine receptors: unraveling the mechanisms of nicotine addiction.Frontiers in neuroscience · 2025Review
- A role for circuitry of the cortical amygdala in excessive alcohol drinking, withdrawal, and alcohol use disorder.Alcohol (Fayetteville, N.Y.) · 2024Review
- Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression.bioRxiv : the preprint server for biology · 2024Article
- Sex differences in neural networks recruited by frontloaded binge alcohol drinking.Addiction biology · 2024Article
- Neural Network Connectivity Following Opioid Dependence is Altered by a Common Genetic Variant in the µ-Opioid Receptor,The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Antagonists of the stress and opioid systems restore the functional connectivity of the prefrontal cortex during alcohol withdrawal through divergent mechanisms.bioRxiv : the preprint server for biology · 2024Article
- UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Network models to enhance the translational impact of cross-species studies.Nature reviews. Neuroscience · 2023Review
- Article
- Hyperconnectivity of two separate long-range cholinergic systems contributes to the reorganization of the brain functional connectivity during nicotine withdrawal in male mice.bioRxiv : the preprint server for biology · 2023Article
- UNRAVELing the synergistic effects of psilocybin and environment on brain-wide immediate early gene expression in mice.bioRxiv : the preprint server for biology · 2023Article
- Whole-brain tracking of cocaine and sugar rewards processing.Translational psychiatry · 2023Article
- Review
- Low intensity repetitive transcranial magnetic stimulation modulates brain-wide functional connectivity to promote anti-correlated c-Fos expression.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Numerous brain regions have been identified as contributing to withdrawal behaviors, but it is unclear the way in which these brain regions as a whole lead to withdrawal. The search for a final common brain pathway that is involved in withdrawal remains elusive. To address this question, we implanted osmotic minipumps containing either saline, nicotine (24 mg/kg/d), cocaine (60 mg/kg/d), or methamphetamine (4 mg/kg/d) for one week in male C57BL/6J mice. After one week, the minipumps were removed and brains collected 8 h (saline, nicotine, and cocaine) or 12 h (methamphetamine) after removal. We then performed single-cell whole-brain imaging of neural activity during the withdrawal period when brains were collected. We used hierarchical clustering and graph theory to identify similarities and differences in brain functional architecture. Although methamphetamine and cocaine shared some network similarities, the main common neuroadaptation between these psychostimulant drugs was a dramatic decrease in modularity, with a shift from a cortical-driven to subcortical-driven network, including a decrease in total hub brain regions. These results demonstrate that psychostimulant withdrawal produces the drug-dependent remodeling of functional architecture of the brain and suggest that the decreased modularity of brain functional networks and not a specific set of brain regions may represent the final common pathway associated with withdrawal.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.