Evidence map›Paper›PMID 34580157›Full record

ArticleeNeuro

Identification of Trigeminal Sensory Neuronal Types Innervating Masseter Muscle.

Karen A Lindquist, Sergei Belugin, Anahit H Hovhannisyan, Tatiana M Corey, Adam Salmon, Armen N Akopian

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  12. Review
  13. Trigeminal somatosensation in the temporomandibular joint and associated disorders.Frontiers in pain research (Lausanne, Switzerland) · 2024
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Transcriptional profiles of non-neuronal and immune cells in mouse trigeminal ganglia.Frontiers in pain research (Lausanne, Switzerland) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Karen A LindquistIntegrated Biomedical Sciences (IBMS) Program, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
Sergei BeluginEndodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
Anahit H HovhannisyanEndodontics, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
Tatiana M CoreyLaboratory Animal Resources Departments, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
Adam SalmonMolecular Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229.
Armen N AkopianIntegrated Biomedical Sciences (IBMS) Program, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 akopian@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · USSouth Texas Veterans Health Care System · US

Funding

TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
LIGHT and Lymphotoxin targeting for the treatment of chronic orofacial pain conditionsR01DE029187 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AKOPIAN, ARMEN N, RUPAREL, SHIVANI B · 2019 to 2021
$3.8M
NIA NIH HHS P30 AG013319NIA NIH HHS P30 AG024824NIDCR NIH HHS R01 DE029187
6 · The paper itself

Abstract

Understanding masseter muscle (MM) innervation is critical for the study of cell-specific mechanisms of pain induced by temporomandibular disorder (TMDs) or after facial surgery. Here, we identified trigeminal (TG) sensory neuronal subtypes (MM TG neurons) innervating MM fibers, masseteric fascia, tendons, and adjusted tissues. A combination of patch clamp electrophysiology and immunohistochemistry (IHC) on TG neurons back-traced from reporter mouse MM found nine distinct subtypes of MM TG neurons. Of these neurons, 24% belonged to non-peptidergic IB-4

Indexed as

Masseter MuscleTRPV Cation ChannelsAnimalsFaceImmunohistochemistryMiceSensory Receptor CellsTRPV Cation Channelsmasseter musclemyogenous temporomandibular disordersorofacial painsensory neuronstrigeminal

Identifiers

PMID34580157
PMCPMC8513531
OpenAlexW3203118316

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.