Evidence map›Paper›PMID 34580126›Full record

ArticleBMJ case reports2021

Immunotherapy-induced coeliac disease in curative lung cancer.

Hannah Walton, Samantha Hopkins, Alan Shand, Shahida Din

Open access · greenAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Hannah WaltonEdinburgh IBD Unit, NHS Lothian, Edinburgh, UK hannah.walton3@nhs.net.ORCID http://orcid.org/0000-0003-4194-7092
Samantha HopkinsDepartment of Medical Oncology, NHS Lothian, Edinburgh, UK.
Alan ShandEdinburgh IBD Unit, NHS Lothian, Edinburgh, UK.
Shahida DinEdinburgh IBD Unit, NHS Lothian, Edinburgh, UK.ORCID http://orcid.org/0000-0003-2855-3400
NHS Lothian · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advent of immunotherapy has revolutionised the treatment of metastatic lung cancer and it has recently been established as the standard of care in the radical treatment of lung cancer. However, immune-related adverse events (IrAEs) frequently occur in patients treated with immunotherapy, and rare IrAEs continue to be identified. We report a case of immunotherapy-induced coeliac disease due to adjuvant durvalumab post-chemoradiotherapy in a patient receiving curative treatment for lung cancer. The patient had raised anti-tissue transglutaminase IgA and histological findings consistent with coeliac disease. This is the first published case report of probable immunotherapy-induced coeliac disease both with the immunotherapy drug durvalumab and in the curative lung cancer setting.

Indexed as

Antineoplastic Agents, ImmunologicalCarcinoma, Non-Small-Cell LungCeliac DiseaseLung NeoplasmsHumansImmunotherapyAntineoplastic Agents, Immunologicalcoeliac diseaseimmunological products and vaccineslung cancer (oncology)unwanted effects / adverse reactions

Identifiers

PMID34580126
PMCPMC8477243
OpenAlexW3202053961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.