Evidence map›Paper›PMID 34580095›Full record

ArticleBMJ open2021

Preferences for pre-exposure prophylaxis (PrEP) among men who have sex with men and transgender women at risk of HIV infection: a multicentre protocol for a discrete choice experiment in Brazil.

Claudia Cristina de Aguiar Pereira, Thiago Silva Torres, Paula Mendes Luz, Brenda Hoagland, Alessandro Farias, Jose David Urbaez Brito, Marcus Vinícius Guimarães Lacerda, Daila Alena Raenck da Silva, Marcos Benedetti, Maria Cristina Pimenta and 2 more

Abstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Claudia Cristina de Aguiar PereiraENSP - National School of Public Health, FIOCRUZ, Rio de Janeiro, Brazil pereirac.claudia@gmail.com.ORCID 0000-0003-1389-9214
Thiago Silva TorresInstituto Nacional de Infectologia Evandro Chagas - INI/FIOCRUZ, FIOCRUZ, Rio de Janeiro, Brazil.ORCID 0000-0002-2557-601X
Paula Mendes LuzInstituto Nacional de Infectologia Evandro Chagas - INI/FIOCRUZ, FIOCRUZ, Rio de Janeiro, Brazil.ORCID 0000-0001-9746-719X
Brenda HoaglandInstituto Nacional de Infectologia Evandro Chagas - INI/FIOCRUZ, FIOCRUZ, Rio de Janeiro, Brazil.ORCID 0000-0001-8210-3748
Alessandro FariasCentro Estadual Especializado em Diagnóstico, Assistência e Pesquisa (CEDAP), Governo do Estado da Bahia, Salvador, Brazil.
Jose David Urbaez BritoHospital Dia Asa Sul, Ministerio da Saude, Brasilia, Brazil.
Marcus Vinícius Guimarães LacerdaFMT, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Brazil.
Daila Alena Raenck da SilvaCentro de Testagem Aconselhamento (CTA) Santa Marta, Porto Alegre Secretaria Municipal de Saude, Porto Alegre, Brazil.
Marcos BenedettiInstituto Nacional de Infectologia Evandro Chagas - INI/FIOCRUZ, FIOCRUZ, Rio de Janeiro, Brazil.
Maria Cristina PimentaDepartamento de Doenças de Condições Crônicas e Infecções Sexualmente Transmissíveis, Ministério da Saúde, Brasilia, Brazil.
Beatriz GrinsztejnInstituto Nacional de Infectologia Evandro Chagas - INI/FIOCRUZ, FIOCRUZ, Rio de Janeiro, Brazil.ORCID 0000-0003-3692-5155
Valdilea Gonçalves VelosoInstituto Nacional de Infectologia Evandro Chagas - INI/FIOCRUZ, FIOCRUZ, Rio de Janeiro, Brazil.ORCID 0000-0002-6622-3165

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPre-exposure prophylaxis (PrEP) is an important and well-established prevention strategy for sexual acquisition of HIV. In Brazil, transgender women (TGW) and men who have sex with men (MSM) bear the largest burden among key populations. Little is known about preferences for PrEP characteristics in these vulnerable populations in Latin America. The goal of this study is to investigate preferences of TGW and MSM with respect to PrEP characteristics, whether current user or not, and to assess any attributes and levels that may improve the decision to start using PrEP (uptake) and optimal continuity of use (adherence), which are important dimensions for PrEP success. METHODS AND ANALYSIS: We hereby outline the protocol of a discrete choice experiment (DCE) to be conducted among TGW and MSM in Brazil. The study will be carried out in two phases. The first phase involves literature review and qualitative approaches including in-depth interviews to inform the development of the DCE (attributes and levels). The second phase entails the DCE survey and supporting questions pertaining to sociodemographic and risk behaviour information. The survey is aimed at current PrEP users and non-users, consisting of two modes of administration: face to face in five Brazilian capitals (Rio de Janeiro, Brasília, Manaus, Porto Alegre and Salvador) and online targeting the entire country. A D-efficient zero-prior blocked experimental design will be used to select 60 paired-profile DCE choice tasks, in which participants will be randomly assigned to one of four groups and presented with a set of 15 choice tasks. The planned sample size is 1000 volunteers. ETHICS, TIMELINE AND DISSEMINATION: The study was approved by Comitê de Ética em Pesquisa-Instituto Nacional de Infectologia Evandro Chagas-INI/FIOCRUZ, CEP/INI, CAAE 28416220.2.1001.5262, approval number 3.979.759 in accordance with the Comissão Nacional de Ética em Pesquisa (CONEP-Brazilian National Board of Research Ethics). The study will be conducted between 2020 and 2021. The results will be disseminated to the scientific community and to the public in general through publications in published in peer-reviewed journals and in scientific conferences.

Indexed as

HIV InfectionsHomosexuality, MalePre-Exposure ProphylaxisTransgender PersonsBrazilFemaleHumansMaleMulticenter Studies as TopicRandomized Controlled Trials as Topichealth economicsHIV & AIDSpreventive medicinepublic health

Identifiers

PMID34580095
PMCPMC8477321

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.