Evidence map›Paper›PMID 34579934›Full record

SynthesisJournal of the American Medical Directors Association2021

Dose-Response Meta-Analysis on Tooth Loss With the Risk of Cognitive Impairment and Dementia.

Xiang Qi, Zheng Zhu, Brenda L Plassman, Bei Wu

Open access · greenAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the American Medical Directors Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 9 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 9 syntheses or guidelines pooled it, 124 citations in OpenAlex.

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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Xiang QiRory Meyers College of Nursing, New York University, New York, NY, USA.
Zheng ZhuSchool of Nursing, Fudan University, Shanghai, China; Fudan University Centre for Evidence-based Nursing: A Joanna Briggs Institute Centre of Excellence, Shanghai, China.
Brenda L PlassmanDepartment of Psychiatry, Duke University, Durham, NC, USA.
Bei WuRory Meyers College of Nursing, New York University, New York, NY, USA; NYU Aging Incubator, New York University, New York, NY, USA. Electronic address: bei.wu@nyu.edu.
New York University · USDuke University · USFudan University · CN

Funding

Diversity supplement to the U01 project-Care partner assisted intervention to improve oral health for person with mild dementiaU01DE027512 · NIDCR · NEW YORK UNIVERSITY · PI ANDERSON, RUTH A, PLASSMAN, BRENDA L · 2018 to 2023
$3.9M
Pathways from co-occurrence of poor oral health and diabetes to Alzheimer's disease and related dementia (ADRD) and mortalityR56AG067619 · NIA · NEW YORK UNIVERSITY · PI LUO, HUABIN, WU, BEI · 2020 to 2020
$519k
NIA NIH HHS R56 AG067619NIDCR NIH HHS U01 DE027512
6 · The paper itself

Abstract

objectivesTo quantify the dose-response associations between tooth loss and risk of cognitive impairment and dementia.

designLongitudinal studies that examined the association between tooth loss and cognitive function were systematically searched on 6 databases through March 1, 2020. The study adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. Risk estimates were pooled using random-effects models. The dose-response associations were assessed using generalized least squares spline models. SETTING AND

participantsAdults from community, institution, outpatient or in-hospital were included in the meta-analysis. MEASURES: Cognitive impairment and dementia were defined by neuropsychological tests, diagnostic criteria, or medical records. Tooth loss was self-reported or assessed by clinical examinations.

resultsFourteen studies were entered into the meta-analysis, including 34,074 participants and 4689 cases with diminished cognitive function. Participants with more tooth loss had a 1.48 times higher risk of developing cognitive impairment [95% confidence interval (CI) 1.18-1.87] and 1.28 times higher risk of being diagnosed with dementia (95% CI 1.09-1.49); however, the association was nonsignificant for participants using dentures (relative risk = 1.10, 95% CI 0.90-1.11). Eight studies were included in the dose-response analysis, and data supported the use of linear models. Each additional tooth loss was associated with a 0.014 increased relative risk of cognitive impairment and 0.011 elevated relative risks of dementia. Edentulous participants faced a 1.54 times higher risk of cognitive impairment and a 1.40 times higher risk of being diagnosed with dementia. CONCLUSIONS AND IMPLICATIONS: Moderate-quality evidence suggested tooth loss was independently associated with cognitive impairment and dementia; risk of diminished cognitive function increased with incremental numbers of teeth lost. Furthermore, timely prosthodontic treatment with dentures may reduce the progression of cognitive decline related to tooth loss.

Indexed as

Cognitive DysfunctionDementiaTooth LossAdultCognitionHumanscognitive declinemeta-analysisOral healthsystematic review

Identifiers

PMID34579934
PMCPMC8479246
OpenAlexW3179409016

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.