Evidence map›Paper›PMID 34579754›Full record

ArticleItalian journal of pediatrics2021

Reasons for SARS-CoV-2 infection in children and their role in the transmission of infection according to age: a case-control study.

Mauro Calvani, Giulia Cantiello, Maria Cavani, Eleonora Lacorte, Bruno Mariani, Valentina Panetta, Pasquale Parisi, Gabriella Parisi, Federica Roccabella, Paola Silvestri and 1 more

Open access · goldAbstract read
In one paragraph

Article in Italian journal of pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 4 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 4 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The role of children in household transmission of COVID-19: a systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. The year 2021 in COVID-19 pandemic in children.Italian journal of pediatrics · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Mauro CalvaniOperative Unit of Pediatrics, San Camillo-Forlanini Hospital, 00151, Rome, Italy. maurocalvani58@gmail.com.
Giulia CantielloDepartment of Maternal, Infantile and Urological Sciences, Sapienza University of Rome, 00161, Rome, Italy.
Maria CavaniDepartment of Maternal, Infantile and Urological Sciences, Sapienza University of Rome, 00161, Rome, Italy.
Eleonora LacorteNational Centre for Disease Prevention and Health Promotion, National Institute of Health, 00161, Rome, Italy.
Bruno MarianiLaboratory of Microbiology and Virology, San Camillo-Forlanini Hospital, 00151, Rome, Italy.
Valentina PanettaL'altrastatistica srl, Consultancy & Training, Biostatistics office, Rome, Italy.
Pasquale ParisiNESMOS Department, Faculty of Medicine & Psychology, "Sapienza" University, c/o Sant'Andrea Hospital, Rome, Italy.
Gabriella ParisiLaboratory of Microbiology and Virology, San Camillo-Forlanini Hospital, 00151, Rome, Italy.
Federica RoccabellaChild Neurology, NESMOS Department, Faculty of Medicine & Psychology, "Sapienza" University, c/o Sant'Andrea Hospital, Rome, Italy.
Paola SilvestriDepartment of Maternal, Infantile and Urological Sciences, Sapienza University of Rome, 00161, Rome, Italy.
Nicola VanacoreDepartment of Maternal, Infantile and Urological Sciences, Sapienza University of Rome, 00161, Rome, Italy.
Sapienza University of Rome · ITCarlo Forlanini Hospital · ITAzienda Ospedaliera Sant'Andrea · ITData Management (Italy) · ITIstituto Superiore di Sanità · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe locations where children get exposed to SARS-CoV-2 infection and their contribution in spreading the infection are still not fully understood. Aim of the article is to verify the most frequent reasons for SARS-CoV-2 infection in children and their role in the secondary transmission of the infection.

methodsA case-control study was performed in all SARS-CoV-2 positive children (n = 81) and an equal number of age- and sex- matched controls who were referred to the S. Camillo-Forlanini Pediatric Walk-in Center of Rome. The results of all SARS-CoV-2 nasopharyngeal swabs performed in children aged < 18 years from October 16 to December 19, 2020 were analyzed.

resultsSchool contacts were more frequent in controls than in cases (OR 0.49; 95% CI: 0.3-0.9), while household contacts were higher in cases (OR 5.09; 95% CI: 2.2-12.0). In both cases and controls, school contacts were significantly less frequent, while on the contrary household contacts seemed to be more frequent in nursery school children compared to primary school or middle/high school children. A multivariate logistic regression showed that the probability of being positive to SARS-CoV-2 was significantly lower in children who had school contacts or who had flu symptoms compared to children who had household contacts. Results showed a 30.6% secondary attack rate for household contacts.

conclusionIn our study population, the two most frequent reasons for SARS-CoV-2 infection were school and home contacts. The risk of being positive was 5 times lower in children who had school contacts than in children who had household contacts.

Indexed as

AdolescentAge FactorsCase-Control StudiesChildChild, PreschoolCOVID-19FemaleHumansIncidenceInfantInfant, NewbornItalyMalePandemicsPneumonia, ViralSARS-CoV-2ChildrenCovid-19Household contactSARS-CoV-2 infectionSchool contactSecondary attack rate

Identifiers

PMID34579754
PMCPMC8474731
OpenAlexW3180617462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.