ArticleBMC musculoskeletal disorders2021
Age-related increase in muscle stiffness is muscle length dependent and associated with muscle force in senior females.
Article in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Muscle elasticity variations in assessing age-related changes in adults - A systematic review.Geriatrics & gerontology international · 2025Pooled it
- Article
- Changes in the mechanical properties and pressure pain thresholds of muscles in patients with fibromyalgia and their relationship with clinical parameters: a case-control study.European journal of applied physiology · 2026Article
- Longitudinal Assessment of Quantitative Metrics for Skeletal Muscle Health Using 3D Rotational Shear Wave Elasticity Imaging in the Vastus Lateralis.Ultrasound in medicine & biology · 2026Article
- Using quantitative imaging methods to investigate the association between quadriceps stiffness and knee cartilage volumes.Bone & joint research · 2026Article
- Muscle-brain crosstalk as a driver of brain health in aging.GeroScience · 2026Review
- How muscle ageing affects rapid goal-directed movement: mechanistic insights from a simple model.PLoS computational biology · 2026Article
- Age-related changes in quadriceps stiffness and strength: a longitudinal observation in community-dwelling older adults.BMC geriatrics · 2025Observational
- Predicting Sarcopenia in Peritoneal Dialysis Patients: A Multimodal Ultrasound-Based Logistic Regression Analysis and Nomogram Model.Diagnostics (Basel, Switzerland) · 2025Article
- Mechanomedicine for Addressing Skeletal Muscle Insulin Resistance.Endocrine reviews · 2025Review
- Knee Flexion Excursion Mediates the Association Between Quadriceps Stiffness and Knee Loads During the Mid-Stance Phase of Gait.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Displacement MMG-based estimation of dynamic muscle viscoelasticity in the quadriceps during passive pedaling.Scientific reports · 2025Article
- Value of Conventional Ultrasound Combined with Shear Wave Elastography for Sarcopenia in Patients with Cardiovascular Disease.Clinical interventions in aging · 2025Article
- Associations amongst dynamic knee stiffness during gait, quadriceps stiffness, and the incidence of knee osteoarthritis over 24 months: a cohort study with a mediation analysis.BMC musculoskeletal disorders · 2024Article
- Association of Muscle Quality and Pain in Adults With Symptomatic Knee Osteoarthritis, Independent of Muscle Strength: Findings From a Cross-Sectional Study.Arthritis & rheumatology (Hoboken, N.J.) · 2024Article
- The effects of myosteatosis on skeletal muscle function in older adults.Physiological reports · 2024Review
- Physiological and Psychological Differences Between 20% Grade Incline Walking and Level-Grade Jogging at Isocaloric Intensity.International journal of exercise science · 2024Article
- Detecting age-related changes in skeletal muscle mechanics using ultrasound shear wave elastography.Scientific reports · 2023Article
- The effect of fatty infiltration, revision surgery, and sex on lumbar multifidus passive mechanical properties.JOR spine · 2023Article
- On the variability and dependence of human leg stiffness across strides during running and some consequences for the analysis of locomotion data.Royal Society open science · 2023Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn aging, muscle stiffness is considered as one of the factors associated with the reduction of force generation capability. There have been inconsistent findings on age-related alteration in the passive stiffness of quadriceps muscle in the female adults. Thus, the aim of this study was to determine the effect of aging on the shear moduli of the superficial muscle heads of the quadriceps and to explore its relationship with knee extension force.
methodsPassive shear moduli of the rectus femoris (RF), vastus lateralis (VL), and vastus medialis (VM) were measured at rest using shear wave elastography in 20 young and 20 senior female adults. Measurements were repeated at four knee joint positions, that is, 30°, 60°, 90°, and 105° of knee flexion. Maximal isometric voluntary knee extension force was assessed at 30°, 60°, and 90° of knee flexion.
resultsAs per our findings, senior adults were determined to have significantly higher passive muscle shear moduli in the RF (by 34% - 68%; all p < 0.05) and the VL muscle heads (by 13%-16%, all p < 0.05) at and beyond 60° of knee flexion. Age-related increase in the VM was evident at 105° knee flexion (by11%, p = 0.020). The RF shear modulus was negatively correlated to the maximal isometric voluntary contraction force measured at 60° (r = - 0.485, p = 0.030) in senior adults.
conclusionsSenior female adults had greater passive stiffness at the superficial muscle heads of the quadriceps muscles when measured at long muscle length. Among the senior female adults, the passive stiffness of RF has been determined to have a negative association with the knee extensor force only at 60° knee flexion. No significant association was noted for other angles and muscles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.