SynthesisBMC infectious diseases2021
The yield of tuberculosis contact investigation in low- and middle-income settings: a systematic review and meta-analysis.
Synthesis in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Number Needed to Screen for Tuberculosis Disease Among Children: A Systematic Review.Pediatrics · 2023Pooled it
- mHealth-supported tuberculosis contact investigation by community health workers in high-burden countries: a scoping review.Global health action · 2026Article
- Household structures and exposure networks among people with multidrug-resistant TB in Namibia.IJTLD open · 2026Article
- Optimization of Case Finding and Preventive Treatment Among Household Contacts of People with Tuberculosis in Zimbabwe.Tropical medicine and infectious disease · 2025Article
- Evaluation of Social and Clinical Factors Associated with Adverse Drug Reactions Among Children with Drug-Resistant Tuberculosis in Pakistan.Tropical medicine and infectious disease · 2025Article
- Innovative timing strategies for tuberculosis household contact investigation: cost-effectiveness analysis from a randomized trial in rural and urban South Africa (Kharituwe Study).EClinicalMedicine · 2025Article
- The yield of tuberculosis contact investigation in São Paulo, Brazil: a community-based cross-sectional study.Epidemiology and infection · 2025Article
- Timing and predictors of disease incidence among named contacts of reported tuberculosis patients in a low incidence setting.PloS one · 2025Article
- Is household contact investigation a missing link for tuberculosis care in Chhattisgarh, India?-Operational research using programmatic data.PLOS global public health · 2025Article
- Active case-finding for TB in India: Assessment of scale and quality benchmarks, time taken and use of rapid molecular diagnostic tests.PLOS global public health · 2025Article
- Risk Factors of Childhood Tuberculosis in the Centre Region of Cameroon: An Unmatched Case-Control Study.Interdisciplinary perspectives on infectious diseases · 2025Article
- Transcriptomic Signatures of Progression to Tuberculosis Disease Among Close Contacts in Brazil.The Journal of infectious diseases · 2024Article
- The Yield of Active Tuberculosis Disease and Latent Tuberculosis Infection in Tuberculosis Household Contacts Investigated Using Chest X-ray in Yogyakarta Province, Indonesia.Tropical medicine and infectious disease · 2024Article
- The Impact of Preventive Treatment for Multidrug- and Rifampin-Resistant Tuberculosis Exceeds Trial-Based Estimates.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Key drivers of the TB epidemic in Suriname and priority actions to reduce incidence and mortality.IJTLD open · 2024Article
- Incidence and risk factors of tuberculosis among 420 854 household contacts of patients with tuberculosis in the 100 Million Brazilian Cohort (2004-18): a cohort study.The Lancet. Infectious diseases · 2024Article
- Costs incurred by people receiving tuberculosis treatment in low-income and middle-income countries: a meta-regression analysis.The Lancet. Global health · 2023Article
- A qualitative exploration of factors that influence the uptake of tuberculosis services by low-skilled migrant workers in Singapore.BMC health services research · 2023Article
- A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial.BMC public health · 2023Article
- A user-centred implementation strategy for tuberculosis contact investigation in Uganda: Protocol for a stepped-wedge, cluster-randomised trial.Research square · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
backgroundContact investigation, the systematic evaluation of individuals in close contact with an infectious tuberculosis (TB) patient, is a key active case-finding strategy for global TB control. Better estimates of the yield of contact investigation can guide strategies to reduce the number of underreported and underdiagnosed TB cases, approximately three million cases per year globally. A systematic review (Prospero ID # CRD42019133380) and meta-analysis was conducted to update and enhance the estimates of the yield of TB contact investigation in low- and middle-income countries (LMIC). Pubmed, Web of Science, Embase and the WHO Global Index Medicus were searched for peer-reviewed studies (published between January 2006-April 2019); studies reporting the number of active TB or latent tuberculosis infection (LTBI) found through contact investigation were included. Pooled data were meta-analyzed using a random effects model and risk of bias was assessed.
resultsOf 1,644 unique citations obtained from database searches, 110 studies met eligibility criteria for descriptive data synthesis and 95 for meta-analysis. The pooled yields of contact investigation activities for different outcomes were: secondary cases of all active TB (defined as those bacteriologically confirmed or clinically diagnosed) 2.87% (2.61-3.14, I
conclusionsThis study provides methodologically rigorous and up-to-date estimates for the yield of TB contact investigation activities in low- and middle-income countries (LMIC). While the data are heterogenous, these findings can inform strategic and programmatic planning for scale up of TB contact investigation activities.
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