Evidence map›Paper›PMID 34579566›Full record

ArticlemBio2021

Genetic Analysis of the Salmonella FliE Protein That Forms the Base of the Flagellar Axial Structure.

Jordan J Hendriksen, Hee Jung Lee, Alexander J Bradshaw, Keiichi Namba, Fabienne F V Chevance, Tohru Minamino, Kelly T Hughes

Abstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. The last bacterial common ancestor encoded a complex flagellum.bioRxiv : the preprint server for biology · 2026
    Article
  2. A β-cap on the FliPQR protein-export channel acts as the cap for initial flagellar rod assembly.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Ring formation byBiophysics and physicobiology · 2023
    Article
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jordan J HendriksenSchool of Biological Sciences, University of Utahgrid.223827.e, Salt Lake City, Utah, USA.
Hee Jung LeeSchool of Biological Sciences, University of Utahgrid.223827.e, Salt Lake City, Utah, USA.
Alexander J BradshawSchool of Biological Sciences, University of Utahgrid.223827.e, Salt Lake City, Utah, USA.
Keiichi NambaGraduate School of Frontiers Bioscience, Osaka Universitygrid.136593.b, Suita, Osaka, Japan.
Fabienne F V ChevanceSchool of Biological Sciences, University of Utahgrid.223827.e, Salt Lake City, Utah, USA.
Tohru MinaminoGraduate School of Frontiers Bioscience, Osaka Universitygrid.136593.b, Suita, Osaka, Japan.
Kelly T HughesSchool of Biological Sciences, University of Utahgrid.223827.e, Salt Lake City, Utah, USA.

Funding

Coupling gene regulation to flagellar morphogenesisR01GM056141 · NIGMS · UNIVERSITY OF WASHINGTON · PI HUGHES, KELLY T · 1998 to 2023
$8.3M
NIGMS NIH HHS R01 GM056141
6 · The paper itself

Abstract

The FliE component of the bacterial flagellum is the first protein secreted through the flagellar type III secretion system (fT3SS) that is capable of self-assembly into the growing bacterial organelle. The FliE protein plays dual roles in the assembly of the Salmonella flagellum as the final component of the flagellar type III secretion system (fT3SS) and as an adaptor protein that anchors the rod (drive shaft) of the flagellar motor to the membrane-imbedded MS-ring structure. This work has identified the interactions between FliE and other proteins at the inner membrane base of the flagellar machine. The

Indexed as

Amino Acid SequenceBacterial ProteinsFlagellaProtein BindingProtein ConformationSalmonella typhimuriumSequence AlignmentType III Secretion SystemsBacterial ProteinsType III Secretion SystemsflagellumFliEgeneticsSalmonellastructuretype 3 secretion

Identifiers

PMID34579566
PMCPMC8546590

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.