Evidence map›Paper›PMID 34579554›Full record

ArticleAutism : the international journal of research and practice2022

Exploring the impact of adolescent cognitive inflexibility on emotional and behavioural problems experienced by autistic adults.

Matthew J Hollocks, Tony Charman, Gillian Baird, Catherine Lord, Andrew Pickles, Emily Simonoff

Open access · hybridAbstract read
In one paragraph

Article in Autism : the international journal of research and practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Executive function challenges persist into young adulthood and predict mental health outcomes in autism.Journal of child psychology and psychiatry, and allied disciplines · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Thinking flexibly: A cognitive remediation therapy-informed intervention for autistic youth.Autism : the international journal of research and practice · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. What Are You Worried About? Content and Extent of Worry in Autistic Adults.Journal of autism and developmental disorders · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Matthew J HollocksKing's College London, UK.ORCID 0000-0002-9513-6917
Tony CharmanKing's College London, UK.ORCID 0000-0003-1993-6549
Gillian BairdEvelina Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, UK.
Catherine LordUCLA Semel Institute for Neuroscience and Human Behavior, USA.ORCID 0000-0001-5633-1253
Andrew PicklesKing's College London and Biomedical Research Centre for Mental Health, UK.
Emily SimonoffKing's College London, UK.ORCID 0000-0002-5450-0823
King's College London · GBGuy's and St Thomas' NHS Foundation Trust · GB

Funding

Medical Research Council G0400065
6 · The paper itself

Abstract

lay abstractAutistic people experience high levels of co-occurring mental health difficulties. To develop more effective treatments, a greater understanding of the thinking processes that may lead to these difficulties is needed. Cognitive inflexibility, defined as a rigid pattern of thoughts and subsequently behaviours, is one possible thinking trait which has previously been associated with both co-occurring mental health difficulties but also other features of autism such as restricted and repetitive behaviours. Restricted and repetitive behaviours include repetitive movements, ritualistic behaviours, and/or highly focused interests. This study investigates the relationship between, cognitive inflexibility, measured using neuropsychological tasks, and emotional and behavioural problems across adolescence and early adulthood. Eighty-one autistic people who were recruited to be representative of the wider autism population were assessed at 16 and 23 years on measures of emotional and behavioural problems, with cognitive inflexibility, restricted and repetitive behaviours and verbal intelligence measured at 16 years. We used statistical modelling to investigate the relationship between cognitive inflexibility and emotional and behavioural symptoms at both timepoints while accounting for the possible relationship with restricted and repetitive behaviours and verbal intelligence quotient. Our results suggest that cognitive inflexibility may be an important factor associated with emotional difficulties across adolescence and early adulthood. This suggests that developing intervention approaches targeting cognitive inflexibility may be an important step in improving the mental health of those with autism.

Indexed as

Autism Spectrum DisorderAutistic DisorderProblem BehaviorAdolescentAdultCognitionHumansStereotyped Behavioranxietyautism spectrum disorderscognition (attention and learningdepressionmemory)psychiatric comorbidity

Identifiers

PMID34579554
PMCPMC9340135
OpenAlexW3202801958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.