Evidence map›Paper›PMID 34579241›Full record

ReviewVaccines2021

Current Progress in the Development of Zika Virus Vaccines.

Kehui Zhou, Chaoqun Li, Wen Shi, Xiaodan Hu, Kutty Selva Nandakumar, Shibo Jiang, Naru Zhang

Open access · goldAbstract readReview
In one paragraph

Review in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A review on Zika vaccine development.Pathogens and disease · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. A hydrogel-entrapped live virus immunization.Nature biomedical engineering · 2023
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Drugs to limit Zika virus infection and implication for maternal-fetal health.Frontiers in virology (Lausanne, Switzerland) · 2022
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kehui ZhouDepartment of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China.
Chaoqun LiDepartment of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China.
Wen ShiDepartment of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China.
Xiaodan HuDepartment of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China.
Kutty Selva NandakumarSchool of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.ORCID 0000-0001-7790-8197
Shibo JiangKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.ORCID 0000-0001-8283-7135
Naru ZhangDepartment of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China.ORCID 0000-0002-8906-1453
Fudan University · CNSouthern Medical University · CN

Funding

Southern Medical University; Scientific Research Foundation of Zhejiang University City College C1034211 and C1051004; J-202106
6 · The paper itself

Abstract

Zika virus (ZIKV) is an arbovirus first discovered in the Americas. ZIKV infection is insidious based on its mild clinical symptoms observed after infection. In Brazil, after 2015, ZIKV infection broke out on a large scale, and many infected pregnant women gave birth to babies with microcephaly. The teratogenic effects of the virus on the fetus and its effects on nerves and the immune system have attracted great attention. Currently, no specific prophylactics or therapeutics are clinically available to treat ZIKV infection. Development of a safe and effective vaccine is essential to prevent the rise of any potential pandemic. In this review, we summarize the latest research on Zika vaccine development based on different strategies, including DNA vaccines, subunit vaccines, live-attenuated vaccines, virus-vector-based vaccines, inactivated vaccines, virus-like particles (VLPs), mRNA-based vaccines, and others. We anticipate that this review will facilitate further progress toward the development of effective and safe vaccines against ZIKV infection.

Indexed as

different strategiesvaccineZika virus

Identifiers

PMID34579241
PMCPMC8472938
OpenAlexW3198505767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.