Evidence map›Paper›PMID 34579167›Full record

ArticleNutrients2021

Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice.

Shanlin Ke, Sarah J Mitchell, Michael R MacArthur, Alice E Kane, David A Sinclair, Emily M Venable, Katia S Chadaideh, Rachel N Carmody, Francine Grodstein, James R Mitchell and 1 more

Abstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Gut microbiota and healthy longevity.Science China. Life sciences · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shanlin KeChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Sarah J MitchellDepartment of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Michael R MacArthurDepartment of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Alice E KanePaul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
David A SinclairPaul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
Emily M VenableDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0002-7436-5817
Katia S ChadaidehDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0003-2251-1170
Rachel N CarmodyDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.
Francine GrodsteinChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
James R MitchellDepartment of Health Sciences and Technology, ETH Zurich, 8005 Zurich, Switzerland.
Yangyu LiuChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-2728-4907

Funding

Therapeutic Control of Aspirin-Exacerbated Respiratory DiseaseU19AI095219 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Maria Gutierrez-Arcelus · 2011 to 2026
$29.1M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Multi-omic approaches to mechanisms of vitamin D, environmental influences, and the microbiome on asthmaUH3OD023268 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI LITONJUA, AUGUSTO A, WEISS, SCOTT T · 2018 to 2022
$13.5M
Role of the Mitochondrial Peptide Humanin in Regulating Aging and HealthspanP01AG055369 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COHEN, PINCHAS · 2018 to 2023
$12.4M
Prospective Study of the Gut Microbiome in AgingRF1AG067744 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T · 2020 to 2020
$11.7M
Functional Redundancy of Human Microbiome and its Implication in Fecal Microbiota TransplantationR01AI141529 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LIU, YANG-YU · 2019 to 2023
$4.5M
SIRT1 as a regulator of health and lifespan of mammalsR37AG028730 · NIA · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2012 to 2021
$4.1M
Long-term health consequences of birth by cesarean sectionR01HD093761 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI CHAVARRO, JORGE EDUARDO · 2018 to 2022
$3.3M
Biodemography of Aging in Wild ChimpanzeesR01AG049395 · NIA · UNIVERSITY OF NEW MEXICO · PI MITANI, JOHN CARY, ROSATI, ALEXANDRA G · 2015 to 2019
$2.9M
Elucidating mechanisms of SIRT1 activationR01DK100263 · NIDDK · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2016 to 2020
$2.5M
Development of a Predictive Frailty Clock & Longitudinal Investigation of its Epigenetic DeterminantsK99AG070102 · NIA · HARVARD MEDICAL SCHOOL · PI KANE, ALICE E · 2021 to 2022
$227k
NIAID NIH HHS R01 AI141529NIA NIH HHS K99 AG070102NIA NIH HHS P01AG055369-01A1NIA NIH HHS R01AG049395NIA NIH HHS R37 AG028730NIDDK NIH HHS R01 DK100263NIH HHS R01AI141529NIH HHS R01DK100263NIH HHS R01HD093761NIH HHS R37AG028730NIH HHS RF1AG067744NIH HHS U01HL089856NIH HHS U19AI095219NIH HHS UH3OD023268
6 · The paper itself

Abstract

Calorie restriction (CR) extends lifespan and retards age-related chronic diseases in most species. There is growing evidence that the gut microbiota has a pivotal role in host health and age-related pathological conditions. Yet, it is still unclear how CR and the gut microbiota are related to healthy aging. Here, we report findings from a small longitudinal study of male C57BL/6 mice maintained on either

Indexed as

AgingGastrointestinal MicrobiomeAnimalsCaloric RestrictionFrailtyHealthy AgingHumansLongevityLongitudinal StudiesMachine LearningMaleMiceMice, Inbred C57BLcalorie restrictiongut microbiotahealthy agingmachine learningmice

Identifiers

PMID34579167
PMCPMC8467910

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.