Evidence map›Paper›PMID 34579157›Full record

ArticleNutrients2021

Dietary Nucleotides Retard Oxidative Stress-Induced Senescence of Human Umbilical Vein Endothelial Cells.

Na Zhu, Xinran Liu, Meihong Xu, Yong Li

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. p16EMBO reports · 2026
    Article
  4. Review
  5. Exogenous Nucleotides Supplementation Attenuates Age-Related Sarcopenia.Journal of cachexia, sarcopenia and muscle · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. 5'-Cytimidine Monophosphate Ameliorates HAntioxidants (Basel, Switzerland) · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Metabolic regulation of endothelial senescence.Frontiers in cardiovascular medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Na ZhuDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Xinran LiuDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Meihong XuDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.
Yong LiDepartment of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.ORCID 0000-0003-3914-5840
Peking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several lines of evidence suggest an inhibitory role of dietary nucleotides (NTs) against oxidative stress and inflammation, which promote senescence in age-associated cardiovascular diseases. We sought to test whether the dietary NTs could retard the hydrogen peroxide (H

Indexed as

beta-GalactosidaseBlotting, WesternCellular SenescenceFlow CytometryHumansHuman Umbilical Vein Endothelial CellsMembrane Potential, MitochondrialMicroscopy, Electron, TransmissionNucleotidesOxidative StressReactive Oxygen Speciesbeta-GalactosidaseNucleotidesReactive Oxygen Speciesdietary nucleotidesHUVECsinflammationmitochondrial functionoxidative stresssenescence

Identifiers

PMID34579157
PMCPMC8472005
OpenAlexW3200386137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.