Evidence map›Paper›PMID 34579125›Full record

Trial reportNutrients2021

The Gut Microbiota during a Behavioral Weight Loss Intervention.

Maggie A Stanislawski, Daniel N Frank, Sarah J Borengasser, Danielle M Ostendorf, Diana Ir, Purevsuren Jambal, Kristen Bing, Liza Wayland, Janet C Siebert, Daniel H Bessesen and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05511337 (Effect of Control in Oxalate and Citrate Intake on Gut Microbiota Composition in Patients With Urolithiasis), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05511337 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Effect of Control in Oxalate and Citrate Intake on Gut Microbiota Composition in Patients With Urolithiasis: Double-blind Randomized Clinical Study

TypeinterventionalSponsorHospital Regional de Alta Especialidad de la Península de YucatánRan2022 to 2025Enrolled60ConditionsUrolithiasisArmsCaloric restriction and control oxalate and citrate foods, Caloric restriction, Real-life intervention with control oxalate and citrate foods
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Intermittent Fasting: Implications for Obesity-Related Colorectal Tumorigenesis.Endocrinology and metabolism clinics of North America · 2025
    Review
  15. Review
  16. Article
  17. Article
  18. The Interplay betweenClinics and practice · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maggie A StanislawskiSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Daniel N FrankSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Sarah J BorengasserSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Danielle M OstendorfSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Diana IrSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Purevsuren JambalSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Kristen BingSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Liza WaylandSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Janet C SiebertSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Daniel H BessesenSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Paul S MacLeanSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Edward L MelansonSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Victoria A CatenacciSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Funding

NIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Suppression of ERalpha in Hematopoietic Stem Cell-Derived Adipocytes Increases Adiposity via Kynurenine and the Aryl Hydrocarbon ReceptorU54AG062319 · NIA · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 2018 to 2026
$13.5M
Comparison of Weight Loss Induced by Intermittent Fasting Versus Daily Caloric Restriction in Individuals with Obesity: A 1-Year Randomized TrialR01DK111622 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI CATENACCI, VICTORIA A · 2017 to 2021
$4.4M
Enhancing Physical Activity Adoption and Maintenance in Adults with Obesity by Understanding Motivation for Exercise: A Mixed Methods Research DesignF32DK122652 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI OSTENDORF, DANIELLE M · 2019 to 2022
$154k
NCATS NIH HHS UL1 TR002535NIDDK NIH HHS P30 DK048520NIDDK NIH HHS R01 DK111622NIH HHS F32 DK122652NIH HHS R01 DK111622NIH HHS U54 AG062319
6 · The paper itself

Abstract

Altered gut microbiota has been linked to obesity and may influence weight loss. We are conducting an ongoing weight loss trial, comparing daily caloric restriction (DCR) to intermittent fasting (IMF) in adults who are overweight or obese. We report here an ancillary study of the gut microbiota and selected obesity-related parameters at the baseline and after the first three months of interventions. During this time, participants experienced significant improvements in clinical health measures, along with altered composition and diversity of fecal microbiota. We observed significant associations between the gut microbiota features and clinical measures, including weight and waist circumference, as well as changes in these clinical measures over time. Analysis by intervention group found between-group differences in the relative abundance of

Indexed as

Behavior TherapyAdultCaloric RestrictionDiet, ReducingFastingFecesFemaleGastrointestinal MicrobiomeHumansMaleMiddle AgedObesityWaist CircumferenceWeight Lossintermittent fastingmicrobiotaobesityweight loss

Identifiers

PMID34579125
PMCPMC8471894

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.