ReviewNutrients2021
Early Pediatric Benefit of Lutein for Maturing Eyes and Brain-An Overview.
Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Impact of MaternalNutrients · 2024Trial
- Bioactive Properties of Carotenoids in Ocular Diseases: Antioxidant, Anti-Inflammatory, and Neuroprotective Effects.Nutrients · 2026Review
- Associations Between Carotenoid Status, Visual Outcomes and Cognitive Metrics in Children: A Scoping Review.Nutrients · 2026Article
- Lutein biosynthesis and pigment dynamics in a partially chlorophyll-deficient mutant of Chlorella sp. under autotrophic, mixotrophic, and heterotrophic cultivation.Biotechnology for biofuels and bioproducts · 2026Article
- Variations in Macular Pigment Optical Density in Children and Adolescents Depending on Time Spent on Smartphones.Vision (Basel, Switzerland) · 2026Article
- "Characterization of visual function parameters in relation to macular pigment optical density in a pediatric population".Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Influence of Dietary Habits on Macular Pigment in Childhood.Journal of clinical medicine · 2025Article
- Extraction and Synthesis of Typical Carotenoids: Lycopene, β-Carotene, and Astaxanthin.Molecules (Basel, Switzerland) · 2024Review
- Longitudinal analysis of carotenoid content in preterm human milk.European journal of pediatrics · 2024Article
- Personalizing Nutrition Strategies: Bridging Research and Public Health.Journal of personalized medicine · 2024Review
- Utilization of Biopolymer-Based Lutein Emulsion as an Effective Delivery System to Improve Lutein Bioavailability in Neonatal Rats.Nutrients · 2024Article
- Article
- Enhancing the stability of lutein emulsions with a water-soluble antioxidant and a oil-soluble antioxidant.Heliyon · 2023Article
- Comparative Genomic Analysis ofMicroorganisms · 2023Article
- Xanthophyll pigments dietary supplements administration and retinal health in the context of increasing life expectancy trend.Frontiers in nutrition · 2023Article
- Lutein and Zeaxanthin Intake during Pregnancy and Visual Function in Offspring at 11-12 Years of Age.Nutrients · 2022Article
Corrections and comments
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Authors and funding
8 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lutein is a dietary carotenoid preferentially accumulated in the eye and the brain in early life and throughout the life span. Lutein accumulation in areas of high metabolism and oxidative stress such as the eye and the brain suggest a unique role of this ingredient during the development and maturation of these organs of common embryological origin. Lutein is naturally provided to the developing baby via the cord blood, breast milk and then infant diet. The presence of this carotenoid depends on fruit and vegetable intakes and its bioavailability is higher in breastmilk. This paper aims to review the anatomical development of the eye and the brain, explore the presence and selective deposition of lutein in these organs during pregnancy and infancy and, based on its functional characteristics, present the latest available research on the beneficial role of lutein in the pediatric population. The potential effects of lutein in ameliorating conditions associated with increase oxidative stress such as in prematurity will be also addressed. Since consumption of lutein rich foods falls short of government guidelines and in most region of the world infant formulas lack this bioactive, dietary recommendations for pregnant and breastfeeding women and their child can help to bridge the gap.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.