Evidence map›Paper›PMID 34579068›Full record

Trial reportNutrients2021

The Effect of Probiotics (MCP

Mohamad Hizami Mohamad Nor, Nurainina Ayob, Norfilza M Mokhtar, Raja Affendi Raja Ali, Geok Chin Tan, Zhiqin Wong, Nor Hamizah Shafiee, Yin Ping Wong, Muaatamarulain Mustangin, Khairul Najmi Muhammad Nawawi

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 15 pooled it
15.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 15 syntheses or guidelines pooled it, 163 citations in OpenAlex.

  1. Pooled it
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  3. ProbioticNarra J · 2025
    Pooled it
  4. Gut Microbiota and Liver Health: Meta-Analysis ofInternational journal of molecular sciences · 2025
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  16. Trial
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  20. Review

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mohamad Hizami Mohamad NorGastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Nurainina AyobDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Norfilza M MokhtarDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-4863-100X
Raja Affendi Raja AliGastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Geok Chin TanGUT Research Group, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-2289-7619
Zhiqin WongGastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Nor Hamizah ShafieeDietetics Programme, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Yin Ping WongDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.ORCID 0000-0003-4897-9927
Muaatamarulain MustanginDepartment of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.
Khairul Najmi Muhammad NawawiGastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia.ORCID 0000-0002-5309-5301
National University of Malaysia · MY

Funding

Ministry of Higher Education, Malaysia FRGS/1/2018/SKK02/UKM/03/2Universiti Kebangsaan Malaysia GGPM-2019-036
6 · The paper itself

Abstract

Treatment for non-alcoholic fatty liver disease (NAFLD) currently consists of lifestyle modifications such as a low-fat diet, weight loss, and exercise. The gut microbiota forms part of the gut-liver axis and serves as a potential target for NAFLD treatment. We investigated the effect of probiotics on hepatic steatosis, fibrosis, and biochemical blood tests in patients with NAFLD. At the small intestinal mucosal level, we examined the effect of probiotics on the expression of CD4+ and CD8+ T lymphocytes, as well as the tight junction protein zona occluden-1 (ZO-1). This was a randomized, double-blind, placebo-controlled trial involving ultrasound-diagnosed NAFLD patients (

Indexed as

BifidobacteriumIntestinal MucosaIntestine, SmallLactobacillusAdultAgedCD8-Positive T-LymphocytesDouble-Blind MethodDysbiosisElasticity Imaging TechniquesFemaleGastrointestinal MicrobiomeHumansImmunityInflammationLivergut microbiotaintestinal permeabilitymucosal immune functionNAFLDprobiotics

Identifiers

PMID34579068
PMCPMC8468225
OpenAlexW3199381301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.