Evidence map›Paper›PMID 34579057›Full record

ArticleNutrients2021

Periconceptional Maternal Diet Characterized by High Glycemic Loading Is Associated with Offspring Behavior in NEST.

Candice L Alick, Rachel L Maguire, Susan K Murphy, Bernard F Fuemmeler, Cathrine Hoyo, John S House

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Candice L AlickCenter for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Rachel L MaguireCenter for Human Health and the Environment, North Carolina State University, Raleigh, NC 27695, USA.
Susan K MurphyDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27701, USA.ORCID 0000-0001-8298-7272
Bernard F FuemmelerDepartment of Health Behavior and Policy, Virginia Commonwealth University, Richmond, VA 23219, USA.
Cathrine HoyoCenter for Human Health and the Environment, North Carolina State University, Raleigh, NC 27695, USA.
John S HouseCenter for Human Health and the Environment, North Carolina State University, Raleigh, NC 27695, USA.ORCID 0000-0002-8447-7871
North Carolina State University · USDuke Medical Center · USNational Institutes of Health · USUniversity of North Carolina at Chapel Hill · USVirginia Commonwealth University · US

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ian Michael Carroll · 1999 to 2026
$31.6M
Translational Research Support CoreP30ES025128 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Sue Fenton · 2015 to 2026
$18.3M
Project 3: Epigenomic Consequences of Early Life Environmental Tobacco Smoke P01ES022831 · NIEHS · DUKE UNIVERSITY · PI MURPHY, SUSAN KAY · 2013 to 2018
$4.1M
Nutrition, Deregulation of Imprinted GenesR01ES016772 · NIEHS · DUKE UNIVERSITY · PI HOYO, CATHRINE · 2009 to 2013
$3.1M
Maternal obesity, child executive functions and child weight gainR01HD084487 · NICHD · DUKE UNIVERSITY · PI FUEMMELER, BERNARD F, SCHECHTER, JULIA CORWIN · 2015 to 2019
$3.0M
Follow-up and Maintenance of the Newborn Epigenetics STudy (NEST) CohortR24ES028531 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI HOYO, CATHRINE, MURPHY, SUSAN KAY · 2018 to 2022
$1.9M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD084487NIDDK NIH HHS P30 DK056350NIEHS NIH HHS P01ES022831NIEHS NIH HHS P30ES025128NIEHS NIH HHS R01ES016772NIEHS NIH HHS R24ES028531U.S. Environmental Protection Agency RD-83543701
6 · The paper itself

Abstract

Maternal periconceptional diets have known associations with proper offspring neurodevelopment. Mechanisms for such associations include improper energy/nutrient balances between mother and fetus, as well as altered offspring epigenetics during development due to maternal nutrient and inflammatory status. Using a comprehensive food frequency questionnaire and assessing offspring temperament with the Infant-Toddler Social and Emotional Assessment (

Indexed as

Glycemic LoadInfant BehaviorChild Behavior DisordersDental AnxietyDietDietary CarbohydratesDNA MethylationFemaleHumansImpulsive BehaviorInfantMaleMaternal Nutritional Physiological PhenomenaPregnancyPrenatal Exposure Delayed EffectsSex FactorsDietary CarbohydratesADHD attention-deficit disorderautism spectrum disorderchild behavior disorderscord blood methylationepigeneticsglycemic indexglycemic loadingimprinted genesmaternal dietneurodevelopment

Identifiers

PMID34579057
PMCPMC8469715
OpenAlexW3199454339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.