ArticleNutrients2021
Protein Intake, Metabolic Status and the Gut Microbiota in Different Ethnicities: Results from Two Independent Cohorts.
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Trial
- Increasing plant protein sources in the diet modulates gut microbiota and tryptophan metabolism in men at cardiometabolic risk.Gut microbes · 2026Trial
- Gut Microbiome-Associated Effects of Plant-Based Diets on Glucose Homeostasis, Body Composition, and Cognitive Function: A Scoping Review.Advances in nutrition (Bethesda, Md.) · 2026Article
- Cross-sectional analyses of metabolites across biological samples mediating dietary acid load and chronic kidney disease.iScience · 2024Article
- Protein supplementation changes gut microbial diversity and derived metabolites in subjects with type 2 diabetes.iScience · 2023Article
- Informatics for your Gut: at the Interface of Nutrition, the Microbiome, and Technology.Yearbook of medical informatics · 2023Review
- Impacts of Dietary Protein and Niacin Deficiency on Reproduction Performance, Body Growth, and Gut Microbiota of Female Hamsters (Tscherskia triton) and Their Offspring.Microbiology spectrum · 2022Article
- Gut Microbiota in Nutrition and Health with a Special Focus on Specific Bacterial Clusters.Cells · 2022Review
- Characterization of the Gut Microbiota in Individuals with Overweight or Obesity during a Real-World Weight Loss Dietary Program: A Focus on the Bacteroides 2 Enterotype.Biomedicines · 2021Article
- Physical Activity and Dietary Composition Relate to Differences in Gut Microbial Patterns in a Multi-Ethnic Cohort-The HELIUS Study.Metabolites · 2021Article
Corrections and comments
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Authors and funding
21 authors at 7 institutions in 5 countries.
Funding
Abstract
backgroundProtein intake has been associated with the development of pre-diabetes (pre-T2D) and type 2 diabetes (T2D). The gut microbiota has the capacity to produce harmful metabolites derived from dietary protein. Furthermore, both the gut microbiota composition and metabolic status (e.g., insulin resistance) can be modulated by diet and ethnicity. However, to date most studies have predominantly focused on carbohydrate and fiber intake with regards to metabolic status and gut microbiota composition.
objectivesTo determine the associations between dietary protein intake, gut microbiota composition, and metabolic status in different ethnicities.
methodsSeparate cross-sectional analysis of two European cohorts (MetaCardis,
resultsIn both cohorts, animal (but not plant) protein intake was associated with pre-T2D status and T2D status after adjustment for confounders. There was no significant association between protein intake (total, animal, or plant) with either gut microbiota alpha diversity or beta diversity, regardless of ethnicity. At the species level, we identified taxonomical signatures associated with animal protein intake that overlapped in both cohorts with different abundances according to metabolic status and ethnicity.
conclusionsAnimal protein intake is associated with pre-T2D and T2D status but not with gut microbiota beta or alpha diversity, regardless of ethnicity. Gut microbial taxonomical signatures were identified, which could function as potential modulators in the association between dietary protein intake and metabolic status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.