Evidence map›Paper›PMID 34579036›Full record

ArticleNutrients2021

Synbiotic Intervention with an Adlay-Based Prebiotic and Probiotics Improved Diet-Induced Metabolic Disturbance in Mice by Modulation of the Gut Microbiota.

Wei-Chung Chiou, Bei-Hau Chang, Hsiao-Hsuan Tien, Yu-Lin Cai, Ya-Chi Fan, Wei-Jen Chen, Hui-Fang Chu, Yu-Hsin Chen, Cheng Huang

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Journal of traditional and complementary medicine · 2025
    Article
  6. Impact ofTranslational gastroenterology and hepatology · 2025
    Article
  7. Article
  8. Nutrients · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Nutrients · 2022
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Wei-Chung ChiouDepartment of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Bei-Hau ChangDivision of Cardiology, Department of Internal Medicine, E-Da Dachang Hospital, Kaohsiung 80794, Taiwan.
Hsiao-Hsuan TienDepartment of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Yu-Lin CaiDepartment of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Ya-Chi FanDepartment of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Wei-Jen ChenSyngen Biotech Co., Ltd., Tainan 73055, Taiwan.
Hui-Fang ChuSyngen Biotech Co., Ltd., Tainan 73055, Taiwan.
Yu-Hsin ChenTaichung District Agricultural Research and Extension Station, Council of Agriculture, Changhua 51544, Taiwan.
Cheng HuangDepartment of Biotechnology and Laboratory Science in Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.ORCID 0000-0001-8220-1815
National Yang Ming Chiao Tung University · TWCouncil of Agriculture · TWE-Da Hospital · TW

Funding

Ministry of Science and Technology, Taiwan MOST 110-2628-B-A49A-501 -
6 · The paper itself

Abstract

Metabolic syndrome and its associated conditions, such as obesity and type 2 diabetes mellitus (T2DM), are a major public health issue in modern societies. Dietary interventions, including microbiota-directed foods which effectively modulate the gut microbiome, may influence the regulation of obesity and associated comorbidities. Although research on probiotics and prebiotics has been conducted extensively in recent years, diets with the use of synbiotics remain relatively unexplored. Here, we investigated the effects of a novel synbiotic intervention, consisting of an adlay seed extrusion cooked (ASEC)-based prebiotic and probiotic (

Indexed as

PrebioticsProbioticsSynbioticsAdipose TissueAnimal FeedAnimalsBacteriaBody WeightDiet, High-FatDysbiosisDyslipidemiasGastrointestinal MicrobiomeInsulin ResistanceMaleMiceObesityPrebioticsadlaygut microbiotahepatic steatosisinsulin resistanceobesitysynbiotic

Identifiers

PMID34579036
PMCPMC8471612
OpenAlexW3200970904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.