ArticleNutrients2021
Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study.
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In one paragraph
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Pooled it
- Associations of circulating advanced glycation end products and their soluble receptors with cancer risk: A systematic review and meta-analysis of observational studies.Glycoconjugate journal · 2024Pooled it
- High glucose enhances NScientific reports · 2026Article
- Integrative analyses of dicarbonyls and advanced glycation end-products with multiomic profiles across tissue, plasma and stool samples reveal methylglyoxal accumulation in colon cancer.Free radical biology & medicine · 2026Article
- Dietary advanced glycation end-products (dAGEs) are not associated with the risk of cancer incidence. A systematic review and meta-analysis of prospective cohort studies.Food science & nutrition · 2024Article
- Article
- Dietary Approach of Patients with Hormone-Related Cancer Based on the Glycemic Index and Glycemic Load Estimates.Nutrients · 2023Review
- Article
- Article
- AGEs and RAGE: metabolic and molecular signatures of the glycation-inflammation axis in malignant or metastatic cancers.Exploration of targeted anti-tumor therapy · 2023Review
- Receptor of advanced glycation end-products axis and gallbladder cancer: A forgotten connection that we should reconsider.World journal of gastroenterology · 2022Review
- Dietary intake of advanced glycation endproducts (AGEs) and cancer risk across more than 20 anatomical sites: A multinational cohort study.Cancer communications (London, England) · 2022Article
- Dietary advanced glycation end products and cancer risk in Japan: From the Takayama study.Cancer science · 2022Article
- Dietary Intake of Advanced Glycation End Products (AGEs) and Mortality among Individuals with Colorectal Cancer.Nutrients · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors at 20 institutions in 11 countries.
Elom K AglagoNutrition and Metabolism Section, International Agency for Research on Cancer (IARC), 69372 Lyon, France.
Ana-Lucia MayénNutrition and Metabolism Section, International Agency for Research on Cancer (IARC), 69372 Lyon, France.
Viktoria KnazeEarly Detection, Prevention, and Infections Branch, International Agency for Research on Cancer (IARC), 69372 Lyon, France.
Heinz FreislingNutrition and Metabolism Section, International Agency for Research on Cancer (IARC), 69372 Lyon, France.ORCID 0000-0001-8648-4998
Veronika FedirkoDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
David J HughesCancer Biology and Therapeutics Group (CBT), Conway Institute, School of Biomolecular and Biomedical Science (SBBS), University College Dublin, D04 V1W8 Dublin, Ireland.ORCID 0000-0003-1668-8770
Li JiaoDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-0237-0262
Anne Kirstine EriksenDanish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Anne TjønnelandDanish Cancer Society Research Center, 2100 Copenhagen, Denmark.ORCID 0000-0003-4385-2097
Marie-Christine Boutron-RuaultCESP, Faculté de Médecine-Université Paris-Saclay, UVSQ, INSERM, 94805 Villejuif, France.
Joseph A RothwellCESP, Faculté de Médecine-Université Paris-Saclay, UVSQ, INSERM, 94805 Villejuif, France.
Gianluca SeveriCESP, Faculté de Médecine-Université Paris-Saclay, UVSQ, INSERM, 94805 Villejuif, France.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Verena KatzkeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Matthias B SchulzeDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany.ORCID 0000-0002-0830-5277
Anna BirukovDepartment of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany.ORCID 0000-0002-8306-3351
Domenico PalliCancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), 50139 Florence, Italy.ORCID 0000-0002-5558-2437
Sabina SieriEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, Italy.ORCID 0000-0001-5201-172X
Maria Santucci de MagistrisAzienda Ospedaliera Universitaria Federico II, 80131 Napoli, Italy.
Rosario TuminoHyblean Association for Epidemiological Research AIRE-ONLUS, 97100 Ragusa, Italy.
Fulvio RicceriDepartment of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano, Italy.
Bas Bueno-de-MesquitaDepartment for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands.
Jeroen W G DerksenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, 3584 CG Utrecht, The Netherlands.ORCID 0000-0002-2973-5583
Guri SkeieFaculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, 9037 Tromsø, Norway.ORCID 0000-0003-2476-4251
Inger Torhild GramFaculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, 9037 Tromsø, Norway.ORCID 0000-0002-0031-4152
Torkjel SandangerFaculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, 9037 Tromsø, Norway.
J Ramón QuirósPublic Health Directorate, 33402 Asturias, Spain.
Leila Luján-BarrosoUnit of Nutrition and Cancer, Catalan Institute of Oncology-ICO; and Nutrition and Cancer Group; Epidemiology, Public Health, Cancer Prevention and Palliative Care Program, Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Av. Granvia 199-203, 08908 Barcelona, Spain.ORCID 0000-0001-6224-1764
Maria-Jose SánchezCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.
Pilar AmianoCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.
María-Dolores ChirlaqueCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.
Aurelio Barricarte GurreaCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.
Ingegerd JohanssonDepartment of Radiation Sciences, Oncology, Umeå University, 907 36 Umeå, Sweden.ORCID 0000-0002-9227-8434
Jonas ManjerDepartment of Clinical Sciences, Malmö, Lund University, 221 00 Lund, Sweden.
Aurora Perez-CornagoCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
Elisabete WeiderpassOffice of the Director, International Agency for Research on Cancer (IARC), 69372 Lyon, France.ORCID 0000-0003-2237-0128
Marc J GunterNutrition and Metabolism Section, International Agency for Research on Cancer (IARC), 69372 Lyon, France.
Alicia K HeathDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK.ORCID 0000-0001-6517-1300
Casper G SchalkwijkDepartment of Internal Medicine, CARIM School for Cardiovascular Diseases, Maastricht University Medical Center, 6229 HX Maastrich, The Netherlands.
Mazda JenabNutrition and Metabolism Section, International Agency for Research on Cancer (IARC), 69372 Lyon, France.
Centre international de recherche sur le cancer · FRInserm · FRUiT The Arctic University of Norway · NODanish Cancer Society · DKGerman Cancer Research Center · DEBaylor College of Medicine · USBiogipuzkoa Health Research Institute · ESCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESFederico II University Hospital · ITFondazione IRCCS Istituto Nazionale dei Tumori · ITGerman Institute of Human Nutrition · DEGobierno del Principado de Asturias · ESImperial College London · GBInstitut d'Investigació Biomédica de Bellvitge · ESInstituto de Salud Pública de Navarra · ESItalian Association for Cancer Research · ITLund University · SEMaastricht University · NLNational Institute for Public Health and the Environment · NLThe University of Texas MD Anderson Cancer Center · US
Funding
Cancer Research UK 29017Medical Research Council MR/M012190/1World Health Organization 001
Abstract
Dietary advanced glycation end-products (dAGEs) have been hypothesized to be associated with a higher risk of colorectal cancer (CRC) by promoting inflammation, metabolic dysfunction, and oxidative stress in the colonic epithelium. However, evidence from prospective cohort studies is scarce and inconclusive. We evaluated CRC risk associated with the intake of dAGEs in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Dietary intakes of three major dAGEs: N
Indexed as
AdultAgedColorectal NeoplasmsDietDiet SurveysEatingEuropeFemaleGlycation End Products, AdvancedHumansMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk AssessmentGlycation End Products, Advancedadvanced glycation end-productscolorectal cancerdietary exposuredietary glycation compounds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.