Evidence map›Paper›PMID 34578990›Full record

ArticleNutrients2021

Partially Hydrolysed Whey-Based Infant Formula Improves Skin Barrier Function.

Sébastien Holvoet, Sophie Nutten, Lénaïck Dupuis, Dominique Donnicola, Tristan Bourdeau, Betsy Hughes-Formella, Dagmar Simon, Hans-Uwe Simon, Ryan S Carvalho, Jonathan M Spergel and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 5 countries.

Sébastien HolvoetDepartment of Gastrointestinal Health, Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., Vers-chez-les-Blanc, 1000 Lausanne, Switzerland.
Sophie NuttenDepartment of Gastrointestinal Health, Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., Vers-chez-les-Blanc, 1000 Lausanne, Switzerland.ORCID 0000-0003-0481-9286
Lénaïck DupuisBiostatistics and Data Management, Clinical Research Unit, Nestlé Research, Société des Produits Nestlé S.A., Vers-chez-les-Blanc, 1000 Lausanne, Switzerland.
Dominique DonnicolaDepartment of Gastrointestinal Health, Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., Vers-chez-les-Blanc, 1000 Lausanne, Switzerland.
Tristan BourdeauDepartment of Gastrointestinal Health, Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., Vers-chez-les-Blanc, 1000 Lausanne, Switzerland.
Betsy Hughes-FormellaExternal Consultant, 21465 Reinbek, Germany.
Dagmar SimonDepartment of Dermatology, Inselspital, Bern University Hospital, 3010 Bern, Switzerland.
Hans-Uwe SimonInstitute of Pharmacology, University of Bern, 3012 Bern, Switzerland.ORCID 0000-0002-9404-7736
Ryan S CarvalhoNestlé Nutrition, 1800 Vevey, Switzerland.
Jonathan M SpergelDepartment of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.
Sibylle KoletzkoDepartment of Pediatrics, Dr. von Hauner Children's Hospital and University Hospital, LMU Munich, 80337 Munich, Germany.
Carine BlanchardDepartment of Gastrointestinal Health, Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé S.A., Vers-chez-les-Blanc, 1000 Lausanne, Switzerland.
Nestlé (Switzerland) · CHChildren's Hospital of Philadelphia · USKrankenhaus Reinbek - Startseite · DELMU Klinikum · DEUniversity Hospital of Bern · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Specific partially hydrolysed whey-based infant formulas (pHF-W) have been shown to decrease the risk of atopic dermatitis (AD) in infants. Historically, AD has been associated primarily with milk allergy; however, defective skin barrier function can be a primary cause of AD. We aimed to ascertain whether oral supplementation with pHF-W can improve skin barrier function. The effect of pHF-W was assessed on transepidermal water loss (TEWL) and antibody productions in mice epicutaneously exposed to

Indexed as

Dietary SupplementsAnimalsAnimals, NewbornAquaporin 3Dermatitis, AtopicHumansHydrolysisImmunoglobulin EInfantInfant FormulaInfant, NewbornKeratinocytesMiceSkinWater Loss, InsensibleWheyAquaporin 3Immunoglobulin EWhey Proteinsaquaporinpartially hydrolysed whey-based infant formulaskin barrier functiontransepidermal water loss

Identifiers

PMID34578990
PMCPMC8472312
OpenAlexW3196549226

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.