Evidence map›Paper›PMID 34578918›Full record

ArticleNutrients2021

High-Fat and Resveratrol Supplemented Diets Modulate Adenosine Receptors in the Cerebral Cortex of C57BL/6J and SAMP8 Mice.

Alejandro Sánchez-Melgar, Pedro José Izquierdo-Ramírez, Verónica Palomera-Ávalos, Mercè Pallàs, José Luis Albasanz, Mairena Martín

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Alejandro Sánchez-MelgarRegional Center of Biomedical Research, Department of Inorganic, Organic and Biochemistry, Faculty of Chemical and Technological Sciences, School of Medicine of Ciudad Real, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain.ORCID 0000-0002-9348-3608
Pedro José Izquierdo-RamírezRegional Center of Biomedical Research, Department of Inorganic, Organic and Biochemistry, Faculty of Chemical and Technological Sciences, School of Medicine of Ciudad Real, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain.
Verónica Palomera-ÁvalosDepartment of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Neuroscience, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0003-3826-9964
Mercè PallàsDepartment of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Institute of Neuroscience, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0003-3095-4254
José Luis AlbasanzRegional Center of Biomedical Research, Department of Inorganic, Organic and Biochemistry, Faculty of Chemical and Technological Sciences, School of Medicine of Ciudad Real, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain.ORCID 0000-0002-9927-5076
Mairena MartínRegional Center of Biomedical Research, Department of Inorganic, Organic and Biochemistry, Faculty of Chemical and Technological Sciences, School of Medicine of Ciudad Real, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain.
University of Castilla-La Mancha · ESUniversitat de Barcelona · ES

Funding

Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR106Junta de Comunidades de Castilla-La Mancha SBPLY/19/180501/000251Ministerio de Ciencia e Innovación PID2019-109206GB-I00Ministerio de Economía y Competitividad PID2019-106285RBUniversidad de Castilla-La Mancha 2020-GRIN-29108
6 · The paper itself

Abstract

Neurodegenerative disorders are devastating diseases in which aging is a major risk factor. High-fat diet (HFD) seems to contribute to cognition deterioration, but the underlying mechanisms are poorly understood. Moreover, resveratrol (RSV) has been reported to counteract the loss of cognition associated with age. Our study aimed to investigate whether the adenosinergic system and plasma membrane cholesterol are modulated by HFD and RSV in the cerebral cortex of C57BL/6J and SAMP8 mice. Results show that HFD induced increased A

Indexed as

AnimalsAntioxidantsCerebral CortexDiet, High-FatMaleMiceMice, Inbred C57BLNeurodegenerative DiseasesReceptors, Purinergic P1ResveratrolAntioxidantsReceptors, Purinergic P1Resveratroladenosine receptorsanimal modelcerebral cortexhigh-fat dietresveratrol

Identifiers

PMID34578918
PMCPMC8466958
OpenAlexW3197777462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.