SynthesisNutrients2021
Effect of Oral Nutritional Supplementation on Growth in Children with Undernutrition: A Systematic Review and Meta-Analysis.
Synthesis in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06160765 (The Efficacy of High Density Formula1.5 kcal/ml or 1 kcal/ml On Catch Up Growth In Growth Faltering Children With Feeding Difficulties), which is not on this map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Efficacy of High Density Formula1.5 kcal/ml or 1 kcal/ml On Catch Up Growth In Growth Faltering Children With Feeding Difficulties
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Liquid Cow's Milk Consumption and Linear Growth Outcomes in Infancy and Childhood: A Systematic Review.Nutrients · 2026Pooled it
- Pooled it
- Egg consumption and growth in children: a meta-analysis of interventional trials.Frontiers in nutrition · 2023Pooled it
- Trial
- Effects of oral nutritional supplement on growth and body composition in malnutrition at risk and malnourished children: MARVEL study, a multi-center randomized controlled trial.European journal of nutrition · 2026Trial
- Comparative Analysis of Nutritional Advice and a Combined Approach for Addressing Impending Stunting in Infants: A Clinical Trial.Nutrients · 2024Trial
- Impact of a Nutrient-Dense Oral Nutritional Supplement on Growth in At-Risk Filipino Children: A Single-Arm Study.Cureus · 2026Article
- Assessment of Hospitalized Patients' Awareness Regarding Food for Special Medical Purposes.Nutrients · 2026Article
- Article
- Predictors of impaired growth during the first year of life: findings from a longitudinal cohort study in Pakistan.Frontiers in nutrition · 2026Article
- Effectiveness of a Tiered Referral System and Early Nutritional Intervention to Prevent and Recover Stunting in Under-Five Indonesian Children.Food science & nutrition · 2025Article
- Impact of Oral Nutritional Supplementation and Dietary Counseling on Outcomes of Linear Catch-Up Growth in Indian Children Aged 3-6.9 Years: Findings from a 6-Month Randomized Controlled Trial.Children (Basel, Switzerland) · 2025Article
- Nutrition-Focused Quality Improvement Programs in Pediatric Care.Children (Basel, Switzerland) · 2024Article
- Predictors of Dietary Supplement Use Among Children Attending Care and Educational Institutions in Krakow, Poland.Nutrients · 2024Observational
- [Early diagnosis and intervention for prepubertal short stature children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- Article
- Exploring the Possible Impact of Oral Nutritional Supplements on Children's Oral Health: An In Vitro Investigation.Dentistry journal · 2024Article
- Protecting optimal childhood growth: systematic nutritional screening, assessment, and intervention for children at risk of malnutrition in the Kingdom of Saudi Arabia.Frontiers in nutrition · 2024Article
- Oral nutritional supplementation with dietary counseling improves linear catch-up growth and health outcomes in children with or at risk of undernutrition: a randomized controlled trial.Frontiers in nutrition · 2024Article
- Optimal Protein Intake in Healthy Children and Adolescents: Evaluating Current Evidence.Nutrients · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral nutritional supplements (ONS) are used to promote catch-up growth in children with undernutrition. We conducted a systematic review and meta-analysis to summarize the evidence of ONS intervention effects on growth for 9-month- to 12-year-old children who were undernourished or at nutritional risk. Eleven randomized controlled trials met the inclusion criteria; trials compared changes in anthropometric measures in children using ONS or ONS + DC (dietary counselling) to measures for those following usual diet or placebo or DC alone. The RCTs included 2287 children without chronic diseases (mean age 5.87 years [SD, 1.35]; 56% boys). At follow-up time points up to 6 months, results showed that children in the ONS intervention group had greater gains in weight (0.423 kg, [95% confidence interval 0.234, 0.613],
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.