Evidence map›Paper›PMID 34578898›Full record

ArticleNutrients2021

Low 25(OH)D Level Is Associated with Severe Course and Poor Prognosis in COVID-19.

Tatiana L Karonova, Alena T Andreeva, Ksenia A Golovatuk, Ekaterina S Bykova, Anna V Simanenkova, Maria A Vashukova, William B Grant, Evgeny V Shlyakhto

Abstract readEvaluation Study
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
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  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Observational
  12. Successful Treatment of a Patient With Severe COVID-19 Using an Integrated Approach Addressing Mast Cells and Their Mediators.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
  13. Article
  14. COVID-19 Pandemic and Cardiovascular Diseases: Lessons and Prospects.Herald of the Russian Academy of Sciences · 2022
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tatiana L KaronovaClinical Endocrinology Laboratory, Department of Endocrinology, Almazov National Medical Research Centre, 194021 Saint-Petersburg, Russia.
Alena T AndreevaClinical Endocrinology Laboratory, Department of Endocrinology, Almazov National Medical Research Centre, 194021 Saint-Petersburg, Russia.ORCID 0000-0002-4878-6909
Ksenia A GolovatukClinical Endocrinology Laboratory, Department of Endocrinology, Almazov National Medical Research Centre, 194021 Saint-Petersburg, Russia.
Ekaterina S BykovaClinical Endocrinology Laboratory, Department of Endocrinology, Almazov National Medical Research Centre, 194021 Saint-Petersburg, Russia.
Anna V SimanenkovaClinical Endocrinology Laboratory, Department of Endocrinology, Almazov National Medical Research Centre, 194021 Saint-Petersburg, Russia.ORCID 0000-0003-3300-1280
Maria A VashukovaBotkin Clinical Infectious Hospital, 195067 Saint-Petersburg, Russia.
William B GrantSunlight, Nutrition, and Health Research Center, P.O. Box 641603, San Francisco, CA 94164-1603, USA.ORCID 0000-0002-1439-3285
Evgeny V ShlyakhtoClinical Endocrinology Laboratory, Department of Endocrinology, Almazov National Medical Research Centre, 194021 Saint-Petersburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated associations between serum 25-hydroxyvitamin D [25(OH)D] level and severity of new coronavirus infection (COVID-19) in hospitalized patients. We assessed serum 25(OH)D level in 133 patients aged 21-93 years. Twenty-five (19%) patients had severe disease, 108 patients (81%) had moderate disease, and 18 (14%) patients died. 25(OH)D level ranged from 3.0 to 97.0 ng/mL (median, 13.5 [25%; 75%, 9.6; 23.3] ng/mL). Vitamin D deficiency was diagnosed in 90 patients, including 37 with severe deficiency. In patients with severe course of disease, 25(OH)D level was lower (median, 9.7 [25%; 75%, 6.0; 14.9] ng/mL), and vitamin D deficiency was more common than in patients with moderate course (median, 14.6 [25%; 75%, 10.6; 24.4] ng/mL,

Indexed as

AgedCOVID-19FemaleHumansMaleMiddle AgedNutritional StatusPrognosisSARS-CoV-2Severity of Illness IndexVitamin DVitamin D Deficiency25-hydroxyvitamin DVitamin D25(OH)DCOVID-19obesityvitamin D deficiency

Identifiers

PMID34578898
PMCPMC8468115

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.