Evidence map›Paper›PMID 34578877›Full record

ArticleNutrients2021

Comparison of the Impact of Xanthohumol and Phenethyl Isothiocyanate and Their Combination on Nrf2 and NF-κB Pathways in HepG2 Cells In Vitro and Tumor Burden In Vivo.

Marta Cykowiak, Violetta Krajka-Kuźniak, Robert Kleszcz, Małgorzata Kucińska, Hanna Szaefer, Hanna Piotrowska-Kempisty, Adam Plewiński, Marek Murias, Wanda Baer-Dubowska

Open access · goldAbstract readComparative Study
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Anticarcinogenic Effects of Isothiocyanates on Hepatocellular Carcinoma.International journal of molecular sciences · 2022
    Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marta CykowiakDepartment of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4, Święcickiego Street, 60-781 Poznań, Poland.
Violetta Krajka-KuźniakDepartment of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4, Święcickiego Street, 60-781 Poznań, Poland.ORCID 0000-0001-7275-0298
Robert KleszczDepartment of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4, Święcickiego Street, 60-781 Poznań, Poland.ORCID 0000-0002-6607-7436
Małgorzata KucińskaDepartment of Toxicology, Poznan University of Medical Sciences, Dojazd 30, 60-631 Poznań, Poland.ORCID 0000-0002-3606-3623
Hanna SzaeferDepartment of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4, Święcickiego Street, 60-781 Poznań, Poland.ORCID 0000-0001-5875-3425
Hanna Piotrowska-KempistyDepartment of Toxicology, Poznan University of Medical Sciences, Dojazd 30, 60-631 Poznań, Poland.
Adam PlewińskiCentre for Advanced Technologies, Adam Mickiewicz University, 10, Uniwersytetu Poznańskiego Street, 61-614 Poznań, Poland.
Marek MuriasDepartment of Toxicology, Poznan University of Medical Sciences, Dojazd 30, 60-631 Poznań, Poland.ORCID 0000-0002-2903-4912
Wanda Baer-DubowskaDepartment of Pharmaceutical Biochemistry, Poznan University of Medical Sciences, 4, Święcickiego Street, 60-781 Poznań, Poland.ORCID 0000-0002-6625-5343
Poznan University of Medical Sciences · PLAdam Mickiewicz University in Poznań · PL

Funding

Narodowe Centrum Nauki 2016/21/B/NZ5/01390
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAnticarcinogenic AgentsApoptosisCyclooxygenase 2 InhibitorsDown-RegulationDrug CombinationsFlavonoidsHepatoblastomaHep G2 CellsHumansIsothiocyanatesLiver NeoplasmsMaleMiceMice, Inbred BALB CMice, NudeAnticarcinogenic AgentsCyclooxygenase 2 InhibitorsDrug CombinationsFlavonoidsIsothiocyanatesNAD(P)H Dehydrogenase (Quinone)NFE2L2 protein, humanNF-E2-Related Factor 2NF-kappa BNQO1 protein, humanphenethyl isothiocyanatePropiophenonesSuperoxide DismutasexanthohumolHepG2 and THLE-2 cellsmice xenograft modelNF-κBNrf2phytochemicals combinations

Identifiers

PMID34578877
PMCPMC8465864
OpenAlexW3197645179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.