Evidence map›Paper›PMID 34578861›Full record

ArticleNutrients2021

Coeliac Disease in Elderly Patients: Value of Coeliac Lymphogram for Diagnosis.

Fernando Fernández-Bañares, Sergio Farrais, Montserrat Planella, Josefa Melero, Natalia López-Palacios, Santiago Vivas, Luis Fernández-Salazar, Ana Pilar Lanzarote, Pablo Ruiz-Ramírez, Marta Aguilar-Criado and 4 more

Abstract readMulticenter Study
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Celiac Disease in the Elderly.Current treatment options in gastroenterology · 2022
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Fernando Fernández-BañaresDepartment of Gastroenterology, Hospital Universitari Mutua Terrassa, 08221 Terrassa, Spain.ORCID 0000-0002-1489-504X
Sergio FarraisDepartment of Gastroenterology, Hospital Fundación Jiménez Díaz, 28040 Madrid, Spain.
Montserrat PlanellaDepartment of Gastroenterology, Hospital Universitari Arnau de Vilanova, 25198 Lleida, Spain.
Josefa MeleroDepartment Immunology and Genetics, Hospital Universitario de Badajoz, 06080 Badajoz, Spain.
Natalia López-PalaciosDepartment of Gastroenterology, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, Spain.
Santiago VivasDepartment of Gastroenterology, Complejo Asistencial Universitario de León, 24071 León, Spain.
Luis Fernández-SalazarDepartment of Gastroenterology, Hospital Clínico Universitario de Valladolid, Gerencia Regional de Salud (SACYL), Facultad de Medicina, Universidad de Valladolid, 47002 Valladolid, Spain.
Ana Pilar LanzaroteDepartment of Gastroenterology, Hospital Fundación Jiménez Díaz, 28040 Madrid, Spain.
Pablo Ruiz-RamírezDepartment of Gastroenterology, Hospital Universitari Mutua Terrassa, 08221 Terrassa, Spain.
Marta Aguilar-CriadoDepartment Immunology and Genetics, Hospital Universitario de Badajoz, 06080 Badajoz, Spain.
Judith VidalDepartment of Flow Cytometry, CATLAB, 08232 Viladecavalls, Spain.
Aureli EsquerdaDepartment of Clinical Laboratory, Hospital Universitari Arnau de Vilanova, 25198 Lleida, Spain.
Cristina SerranoDepartment of Clinical Immunology, Hospital Fundación Jiménez Díaz, 28040 Madrid, Spain.
Concepción NúñezLaboratorio de Investigación en Genética de Enfermedades Complejas, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.ORCID 0000-0002-9489-1603

Funding

Instituto de Salud Carlos III PI18/0089
6 · The paper itself

Abstract

(1) Background: Although a meta-analysis reported that the sensitivity of CD3+ TCRγδ+ cells for coeliac disease diagnosis was >93%, a recent study has suggested that sensitivity decreased to 65% in elderly patients. (2) Aim: To evaluate whether the sensitivity of intraepithelial lymphocyte cytometric patterns for coeliac disease diagnosis changes with advanced age. (3) Methods: We performed a multicentre study including 127 coeliac disease patients ≥ 50 years: 87 with baseline cytometry (45 aged 50-59 years; 23 aged 60-69 years; 19 aged ≥ 70 years), 16 also with a follow-up cytometry (on a gluten-free diet); and 40 with only follow-up cytometry. (4) Results: In Marsh 3 patients, a sensitivity of 94.7%, 88.9% and 86.7% was observed for each age group using a cut-off value of TCRγδ+ >10% (

Indexed as

AgedCeliac DiseaseFemaleFlow CytometryGeriatric AssessmentHumansIntestinal MucosaLymphocyte CountMaleMiddle AgedRetrospective StudiesSensitivity and SpecificityCD3−coeliacelderlyflow cytometryTCRγδ+

Identifiers

PMID34578861
PMCPMC8467369

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.