Concurrent Chemoradiotherapy Induces Body Composition Changes in Locally Advanced Head and Neck Squamous Cell Carcinoma: Comparison between Oral Cavity and Non-Oral Cavity Cancer.

Yu-Ching Lin, Hang Huong Ling, Pei-Hung Chang, Yi-Ping Pan, Cheng-Hsu Wang, Wen-Chi Chou, Fang-Ping Chen, Kun-Yun Yeh

Abstract readComparative Study

In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Yu-Ching LinDepartment of Medical Imaging and Intervention, Chang Gung Memorial Hospital, College of Medicine, Keelung & Chang Gung University, Taoyuan 333007, Taiwan.ORCID 0000-0002-2318-8507

Hang Huong LingDivision of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, College of Medicine, Keelung & Chang Gung University, Taoyuan 333007, Taiwan.ORCID 0000-0003-4662-1235

Pei-Hung ChangDivision of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, College of Medicine, Keelung & Chang Gung University, Taoyuan 333007, Taiwan.

Yi-Ping PanDepartment of Nutrition, Chang Gung Memorial Hospital, Keelung 20401, Taiwan.

Cheng-Hsu WangDivision of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, College of Medicine, Keelung & Chang Gung University, Taoyuan 333007, Taiwan.

Wen-Chi ChouDivision of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, College of Medicine, Linkou & Chang Gung University, Taoyuan 333007, Taiwan.

Fang-Ping ChenOsteoporosis Prevention and Treatment Center, Chang Gung Memorial Hospital, Keelung 20401, Taiwan.ORCID 0000-0001-5228-5755

Kun-Yun YehDivision of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, College of Medicine, Keelung & Chang Gung University, Taoyuan 333007, Taiwan.ORCID 0000-0001-5572-7897

Funding

Chang Gung Memorial Hospital CMRPG2E0101-CMRPG2E0103, CMRPG2J0171, CMRPG2G0611, and CORPG2F0011-13Ministry of Science and Technology, Taiwan MOST 108-2314-B-182A-018-MY3

6 · The paper itself

Abstract

Few prospective cohort trials have evaluated the difference in treatment-interval total body composition (TBC) changes assessed by dual-energy X-ray absorptiometry (DXA) between two patient subgroups with locally advanced head and neck squamous cell carcinoma (LAHNSCC) receiving concurrent chemoradiotherapy (CCRT): oral cavity cancer with adjuvant CCRT (OCC) and non-oral cavity with primary CCRT (NOCC). This study prospectively recruited patients with LAHNSCC. Clinicopathological variables, blood nutritional/inflammatory markers, CCRT-related factors, and TBC data assessed by DXA before and after treatment were collected. Multivariate linear regression analysis identified the factors associated with treatment-interval changes in body composition parameters, including lean body mass (LBM), total fat mass (TFM), and bone mineral content (BMC). A total of 127 patients (OCC (

Indexed as

Body CompositionBone DensityChemoradiotherapyCohort StudiesFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedMouth NeoplasmsProspective StudiesSquamous Cell Carcinoma of Head and Neckbone mineral contentconcurrent chemoradiotherapyDXAhead and neck cancerlean body masstotal fat mass

Identifiers

PMID34578846

DOI10.3390/nu13092969

PMCPMC8472371

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.