Evidence map›Paper›PMID 34578835›Full record

SynthesisNutrients2021

It Is High Time for Personalized Dietary Counseling in Celiac Disease: A Systematic Review and Meta-Analysis on Body Composition.

Zsófia Vereczkei, Nelli Farkas, Péter Hegyi, Marcell Imrei, Mária Földi, Zsolt Szakács, Szabolcs Kiss, Margit Solymár, Rita Nagy, Judit Bajor

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Celiac Disease: Beyond Diet and Food Awareness.Foods (Basel, Switzerland) · 2025
    Review
  7. Article
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Zsófia VereczkeiInstitute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Nelli FarkasInstitute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Péter HegyiInstitute for Translational Medicine, Szentágothai Research Centre, Medical School, University of Pécs, 7624 Pécs, Hungary.
Marcell ImreiInstitute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0003-0175-7462
Mária FöldiInstitute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Zsolt SzakácsInstitute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0002-7035-941X
Szabolcs KissInstitute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0001-5032-866X
Margit SolymárInstitute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.
Rita NagyInstitute for Translational Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0002-2663-4912
Judit BajorDivision of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.ORCID 0000-0002-3941-4871
University of Pecs · HUUniversity of Szeged · HUHeim Pál Országos Gyermekgyógyászati Intézet · HUSemmelweis University · HU

Funding

Economic Development and Innovation Operational Programme Grant (GINOP-2.3.2-15-2016-00048 - STAY ALIVE and GINOP-2.3.4-15-2020-00010 Competence Center for Health Data Analysis, Data Utilisation and Smart Device and Technology Development at the Universit GINOP-2.3.2-15-2016-00048 - STAY ALIVE and GINOP-2.3.4-15-2020-00010
6 · The paper itself

Abstract

The body composition of patients with celiac disease (CD), on which the effects of a gluten-free diet (GFD) are controversial, differs from that of the average population. In this study, we aimed to compare the body composition across CD patients before a GFD, CD patients after a one-year GFD and non-celiac control subjects. A systematic search was conducted using five electronic databases up to 15 July 2021 for studies that reported at least one of the pre-specified outcomes. In meta-analyses, weighted mean differences (WMDs) with 95% confidence intervals (CIs) were calculated. A total of 25 studies were eligible for systematic review, seven of which were included in meta-analysis. During a ≥1-year GFD, fat mass of CD patients, compared to that at baseline, significantly increased (WMD = 4.1 kg, 95% CI = 1.5 to 6.6, three studies). In CD patients after a ≥1-year GFD, compared to non-celiac controls, fat mass (WMD = -5.8 kg, 95% CI = -8.7 to -2.9, three studies) and fat-free mass (WMD = -1.9 kg, 95% CI = -3.0 to -0.7, three studies) were significantly lower. In conclusion, body composition-related parameters of CD patients differ from that of the non-celiac control subjects even after a longstanding GFD.

Indexed as

Adipose TissueBody CompositionCeliac DiseaseCounselingDatabases, FactualDiet, Gluten-FreeHumansPrecision Medicinebody compositionceliac diseasegluten-free diet

Identifiers

PMID34578835
PMCPMC8466091
OpenAlexW3193920322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.