Evidence map›Paper›PMID 34578772›Full record

ArticleNanomaterials (Basel, Switzerland)2021

3D Printed Multi-Functional Scaffolds Based on Poly(ε-Caprolactone) and Hydroxyapatite Composites.

Fan Liu, Honglei Kang, Zhiwei Liu, Siyang Jin, Guoping Yan, Yunlong Sun, Feng Li, Haifei Zhan, Yuantong Gu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

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  13. Nanomechanics and Plasticity.Nanomaterials (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Fan LiuSchool of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China.
Honglei KangDepartment of Orthopaedics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Zhiwei LiuSchool of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China.
Siyang JinSchool of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China.
Guoping YanSchool of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430205, China.
Yunlong SunDepartment of Orthopaedics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Feng LiDepartment of Orthopaedics, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Haifei ZhanDepartment of Civil Engineering, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-0008-545X
Yuantong GuSchool of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD 4001, Australia.
Wuhan Institute of Technology · CNHuazhong University of Science and Technology · CNQueensland University of Technology · AU

Funding

Australian Research Council Discovery Project Grant No. DP180103009Frontier Project of Application Foundation of Wuhan Former Funded Science and Technology Program 2020020601012252Innovative Talents Project of Yellow Crane Talents Plan of Wuhan City Grant [2017] No.1National Key R&D Program of China 2016YFB1101302National Key R&D Program of China 2018YFB1105502Scientific research projects for high level talents in the new century of Hubei Province [2017] No.344
6 · The paper itself

Abstract

3D Printed biodegradable polymeric scaffolds are critical to repair a bone defect, which can provide the individual porous and network microenvironments for cell attachment and bone tissue regeneration. Biodegradable PCL/HA composites were prepared with the blending of poly(ε-caprolactone) (PCL) and hydroxyapatite nanoparticles (HA). Subsequently, the PCL/HA scaffolds were produced by the melting deposition-forming method using PCL/HA composites as the raw materials in this work. Through a serial of in vitro assessments, it was found that the PCL/HA composites possessed good biodegradability, low cell cytotoxicity, and good biocompatibility, which can improve the cell proliferation of osteoblast cells MC3T3-E1. Meanwhile, in vivo experiments were carried out for the rats with skull defects and rabbits with bone defects. It was observed that the PCL/HA scaffolds allowed the adhesion and penetration of bone cells, which enabled the growth of bone cells and bone tissue regeneration. With a composite design to load an anticancer drug (doxorubicin, DOX) and achieve sustained drug release performance, the multifunctional 3D printed PCL/HA/DOX scaffolds can enhance bone repair and be expected to inhibit probably the tumor cells after malignant bone tumor resection. Therefore, this work signifies that PCL/HA composites can be used as the potential biodegradable scaffolds for bone repairing.

Indexed as

3D printed scaffoldsbiodegradabilitybone tissue regenerationhydroxyapatitepoly(ε-caprolactone)

Identifiers

PMID34578772
PMCPMC8465550
OpenAlexW3163275414

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.