Evidence map›Paper›PMID 34578771›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Cytostatic and Cytotoxic Effects of Hollow-Shell Mesoporous Silica Nanoparticles Containing Magnetic Iron Oxide.

Manuel Pérez-Garnes, Victoria Morales, Raul Sanz, Rafael A García-Muñoz

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Synthesis of Multi-Stimuli Responsive FeMolecules (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Manuel Pérez-GarnesDepartment of Chemical and Environmental Technology, Rey Juan Carlos University, C/Tulipán s/n, 28933 Madrid, Spain.
Victoria MoralesDepartment of Chemical and Environmental Technology, Rey Juan Carlos University, C/Tulipán s/n, 28933 Madrid, Spain.ORCID 0000-0002-1609-2099
Raul SanzDepartment of Chemical and Environmental Technology, Rey Juan Carlos University, C/Tulipán s/n, 28933 Madrid, Spain.ORCID 0000-0002-0198-2443
Rafael A García-MuñozDepartment of Chemical and Environmental Technology, Rey Juan Carlos University, C/Tulipán s/n, 28933 Madrid, Spain.ORCID 0000-0002-9091-8733
Universidad Rey Juan Carlos · ES

Funding

Agencia Estatal de Investigación CTQ2014-57858-RAgencia Estatal de Investigación CTQ2017-88642-R
6 · The paper itself

Abstract

Among the different types of nanoparticles used in biomedical applications, Fe nanoparticles and mesoporous siliceous materials have been extensively investigated because of their possible theranostic applications. Here, we present hollow-shell mesoporous silica nanoparticles that encapsulate iron oxide and that are prepared using a drug-structure-directing agent concept (DSDA), composed of the model drug tryptophan modified by carbon aliphatic hydrocarbon chains. The modified tryptophan can behave as an organic template that allows directing the hollow-shell mesoporous silica framework, as a result of its micellisation and subsequent assembly of the silica around it. The one-pot synthesis procedure facilitates the incorporation of hydrophobically stabilised iron oxide nanoparticles into the hollow internal silica cavities, with the model drug tryptophan in the shell pores, thus enabling the incorporation of different functionalities into the all-in-one nanoparticles named mesoporous silica nanoparticles containing magnetic iron oxide (Fe

Indexed as

drug delivery systemsdrug-structure-directing agent (DSDA)hollow-shell mesoporous silica nanoparticlesiron oxide magnetic nanoparticlestoxicity

Identifiers

PMID34578771
PMCPMC8467190
OpenAlexW3200165358

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.