Evidence map›Paper›PMID 34578755›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Chitosan-Coated PLGA Nanoparticles Loaded with

Hassan Mohamed El-Said Azzazy, Sherif Ashraf Fahmy, Noha Khalil Mahdy, Meselhy Ragab Meselhy, Udo Bakowsky

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 61 citations in OpenAlex.

  1. Review
  2. Review
  3. Biofilm-Responsive Nanoplatforms for Infected Wound Reconstruction.International journal of nanomedicine · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Development of Polymeric Nanoparticles Loaded withInternational journal of molecular sciences · 2025
    Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Improved antimicrobial activities ofNanoscale advances · 2024
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Hassan Mohamed El-Said AzzazyDepartment of Chemistry, School of Sciences & Engineering, The American University in Cairo, AUC Avenue, New Cairo 11835, Egypt.
Sherif Ashraf FahmyDepartment of Chemistry, School of Sciences & Engineering, The American University in Cairo, AUC Avenue, New Cairo 11835, Egypt.ORCID 0000-0003-3056-8281
Noha Khalil MahdyDepartment of Chemistry, School of Sciences & Engineering, The American University in Cairo, AUC Avenue, New Cairo 11835, Egypt.
Meselhy Ragab MeselhyDepartment of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo 11562, Egypt.ORCID 0000-0002-3488-7522
Udo BakowskyDepartment of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany.ORCID 0000-0002-3895-0453
American University in Cairo · EGCairo University · EGPhilipps University of Marburg · DE

Funding

The American University in Cairo SSE -CHEM -H.A. -FY21 -FY22 -RG (2-20) -2020-Feb-28-21-32-34
6 · The paper itself

Abstract

Wound healing is a major healthcare concern, and complicated wounds may lead to severe outcomes such as septicemia and amputations. To date, management choices are limited, which warrants the search for new potent wound healing agents. Natural products loaded in poly (lactic-co-glycolic acid) (PLGA) coated with chitosan (CS) constitute a promising antibacterial wound healing formulation. In this work, harmala alkaloid-rich fraction (HARF) loaded into PLGA nanoparticles coated with chitosan (H/CS/PLGA NPs) were designed using the emulsion-solvent evaporation method. Optimization of the formulation variables (HARF: PLGA and CS: PLGA weight ratios, sonication time) was performed using the 3

Indexed as

antibacterialBox–Behnken designchitosan-coated PLGA nanoparticlesPeganum harmala alkaloidswound healing

Identifiers

PMID34578755
PMCPMC8464825
OpenAlexW3201406018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.