Evidence map›Paper›PMID 34578584›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Magnetic Nanoprobes for Spatio-Mechanical Manipulation in Single Cells.

Iuliia P Novoselova, Andreas Neusch, Julia-Sarita Brand, Marius Otten, Mohammad Reza Safari, Nina Bartels, Matthias Karg, Michael Farle, Ulf Wiedwald, Cornelia Monzel

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Iuliia P NovoselovaExperimental Medical Physics, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0001-8041-9319
Andreas NeuschExperimental Medical Physics, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0001-8020-9311
Julia-Sarita BrandExperimental Medical Physics, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Marius OttenColloids and Nanooptics, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Mohammad Reza SafariExperimental Medical Physics, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Nina BartelsExperimental Medical Physics, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Matthias KargColloids and Nanooptics, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0002-6247-3976
Michael FarleCenter for Nanointegration (CENIDE), Faculty of Physics, University of Duisburg-Essen, 47057 Duisburg, Germany.ORCID 0000-0002-1864-3261
Ulf WiedwaldCenter for Nanointegration (CENIDE), Faculty of Physics, University of Duisburg-Essen, 47057 Duisburg, Germany.ORCID 0000-0002-3209-4078
Cornelia MonzelExperimental Medical Physics, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0003-0892-3427
Heinrich Heine University Düsseldorf · DEUniversity of Duisburg-Essen · DEForschungszentrum Jülich · DE

Funding

Deutsche Forschungsgemeinschaft INST 208/749-1 FUGGDeutsche Forschungsgemeinschaft SFB1208 (ID267205415)Fonds der Chemischen Industrie n.a.Volkswagen Foundation Freigeist Fellowship (Aktenzeichen: 94195)
6 · The paper itself

Abstract

Magnetic nanoparticles (MNPs) are widely known as valuable agents for biomedical applications. Recently, MNPs were further suggested to be used for a remote and non-invasive manipulation, where their spatial redistribution or force response in a magnetic field provides a fine-tunable stimulus to a cell. Here, we investigated the properties of two different MNPs and assessed their suitability for spatio-mechanical manipulations: semisynthetic magnetoferritin nanoparticles and fully synthetic 'nanoflower'-shaped iron oxide nanoparticles. As well as confirming their monodispersity in terms of structure, surface potential, and magnetic response, we monitored the MNP performance in a living cell environment using fluorescence microscopy and asserted their biocompatibility. We then demonstrated facilitated spatial redistribution of magnetoferritin compared to 'nanoflower'-NPs after microinjection, and a higher magnetic force response of these NPs compared to magnetoferritin inside a cell. Our remote manipulation assays present these tailored magnetic materials as suitable agents for applications in magnetogenetics, biomedicine, or nanomaterial research.

Indexed as

iron oxide nanoparticlesmagnetoferritinmagnetogeneticsremote particle manipulation

Identifiers

PMID34578584
PMCPMC8471295
OpenAlexW3196844060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.