Evidence map›Paper›PMID 34578463›Full record

ReviewViruses2021

Mutation Rates, Mutation Frequencies, and Proofreading-Repair Activities in RNA Virus Genetics.

Esteban Domingo, Carlos García-Crespo, Rebeca Lobo-Vega, Celia Perales

Abstract readReview
In one paragraph

Review in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed.

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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Esteban DomingoCentro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain.
Carlos García-CrespoCentro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain.ORCID 0000-0001-6561-5389
Rebeca Lobo-VegaDepartment of Clinical Microbiology, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz University Hospital, Universidad Autónoma de Madrid (IIS-FJD, UAM), Av. Reyes Católicos 2, 28040 Madrid, Spain.ORCID 0000-0002-4882-6763
Celia PeralesCentro de Biología Molecular "Severo Ochoa" (CSIC-UAM), Consejo Superior de Investigaciones Científicas (CSIC), Campus de Cantoblanco, 28049 Madrid, Spain.

Funding

Comunidad de Madrid PEJD-2019-PRE/BMD-16414Comunidad de Madrid S2013/ABI-2906Comunidad de Madrid S2018/BAA-4370Instituto de Salud Carlos III CPII19/00001Instituto de Salud Carlos III PI18/00210Ministerio de Ciencia, Innovación y Universidades BFU2017-91384-EXPMinisterio de Ciencia, Innovación y Universidades PRE2018-083422Ministerio de Ciencia, Innovación y Universidades SAF2017-87846-RMinisterio de Economía y Competitividad SAF2014-52400-R
6 · The paper itself

Abstract

The error rate displayed during template copying to produce viral RNA progeny is a biologically relevant parameter of the replication complexes of viruses. It has consequences for virus-host interactions, and it represents the first step in the diversification of viruses in nature. Measurements during infections and with purified viral polymerases indicate that mutation rates for RNA viruses are in the range of 10

Indexed as

Genome, ViralMutationRNA, ViralAnimalsBiological EvolutionCoronavirusExonucleasesGenetic VariationHumansMutation RateRNA VirusesRNA Virus InfectionsVirus ReplicationExonucleasesRNA, Viralerror catastropheexonucleasequasispeciesRNA virusSARS-CoV-2virus diversification

Identifiers

PMID34578463
PMCPMC8473064

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.