Evidence map›Paper›PMID 34578459›Full record

ArticleViruses2021

Neonatal Development in Prenatally Zika Virus-Exposed Infant Macaques with Dengue Immunity.

Karla Ausderau, Sabrina Kabakov, Elaina Razo, Ann M Mitzey, Kathryn M Bach, Chelsea M Crooks, Natalie Dulaney, Logan Keding, Cristhian Salas-Quinchucua, Lex G Medina-Magües and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Macaque Models of Prenatal and Postnatal Zika Virus Exposure and Developmental Outcomes.Journal of the Pediatric Infectious Diseases Society · 2025
    Review
  5. Article
  6. Article
  7. Nonhuman primate models of pediatric viral diseases.Frontiers in cellular and infection microbiology · 2024
    Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 1 country.

Karla AusderauDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
Sabrina KabakovDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
Elaina RazoDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792, USA.
Ann M MitzeyDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Kathryn M BachDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
Chelsea M CrooksDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-3874-4577
Natalie DulaneyDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
Logan KedingDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Cristhian Salas-QuinchucuaDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Lex G Medina-MagüesDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-4242-6945
Andrea M WeilerWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Mason BlissWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Jens EickhoffDepartment of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53792, USA.
Heather A SimmonsWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.ORCID 0000-0002-4862-7289
Andres MejiaWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Kathleen M AntonyDepartment of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI 53705, USA.ORCID 0000-0003-3537-8030
Terry MorganCenter for Developmental Health, Department of Obstetrics and Gynecology, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR 97239, USA.
Saverio CapuanoWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.
Mary L SchneiderDepartment of Kinesiology, Occupational Therapy Program, University of Wisconsin-Madison, Madison, WI 53706, USA.
Matthew T AliotaDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Minneapolis, MN 55108, USA.ORCID 0000-0002-6902-9149
Thomas C FriedrichDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
David H O'ConnorWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.ORCID 0000-0003-2139-470X
Thaddeus G GolosDepartment of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Emma L MohrDepartment of Pediatrics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792, USA.ORCID 0000-0003-0742-305X
University of Wisconsin–Madison · USOregon Health & Science University · USUniversity of Minnesota · US

Funding

WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
Zika virus pathophysiology during pregnancyP01AI132132 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR, DAVID H. · 2018 to 2022
$10.2M
Parasitology and Vector Biology Training ProgramT32AI007414 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI Lyric Colleen Bartholomay · 1992 to 2026
$4.5M
Early neural predictors and neuropathogenesis of sensorimotor neurodevelopmental deficits in macaque infants exposed to Zika virus in uteroR01AI153130 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI AUSDERAU, KARLA KAYE, MOHR, EMMA L · 2020 to 2024
$3.8M
Previous exposure to dengue as a risk factor for Zika during pregnancyR01AI132563 · NIAID · UNIVERSITY OF MINNESOTA · PI ALIOTA, MATTHEW T · 2018 to 2022
$2.8M
Defining maternal and neonatal antibody responses in congenital Zika virus infectionK08AI139341 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI MOHR, EMMA L · 2019 to 2023
$1.0M
NIAID NIH HHS K08 AI139341NIAID NIH HHS P01 AI132132NIAID NIH HHS R01 AI132563NIAID NIH HHS R01 AI153130NIAID NIH HHS T32 AI007414NIH HHS AAH9849NIH HHS AI116382NIH HHS AI132132NIH HHS AI138647NIH HHS P51 OD011106
6 · The paper itself

Abstract

Infants exposed to Zika virus (ZIKV) prenatally may develop birth defects, developmental deficits, or remain asymptomatic. It is unclear why some infants are more affected than others, although enhancement of maternal ZIKV infection via immunity to an antigenically similar virus, dengue virus (DENV), may play a role. We hypothesized that DENV immunity may worsen prenatal ZIKV infection and developmental deficits in offspring. We utilized a translational macaque model to examine how maternal DENV immunity influences ZIKV-exposed infant macaque neurodevelopment in the first month of life. We inoculated eight macaques with prior DENV infection with ZIKV, five macaques with ZIKV, and four macaques with saline. DENV/ZIKV-exposed infants had significantly worse visual orientation skills than ZIKV-exposed infants whose mothers were DENV-naive, with no differences in motor, sensory or state control development. ZIKV infection characteristics and pregnancy outcomes did not individually differ between dams with and without DENV immunity, but when multiple factors were combined in a multivariate model, maternal DENV immunity combined with ZIKV infection characteristics and pregnancy parameters predicted select developmental outcomes. We demonstrate that maternal DENV immunity exacerbates visual orientation and tracking deficits in ZIKV-exposed infant macaques, suggesting that human studies should evaluate how maternal DENV immunity impacts long-term neurodevelopment.

Indexed as

Pregnancy Complications, InfectiousZika Virus InfectionAnimalsAnimals, NewbornAntibodies, ViralDengueDengue VirusDisease Models, AnimalFemaleFetal DevelopmentMacaca mulattaMotor ActivityNervous SystemOrientationPregnancyPrenatal Exposure Delayed EffectsAntibodies, Viralmacaque modelmaternal DENV infectionneurodevelopmentprenatal ZIKV exposure

Identifiers

PMID34578459
PMCPMC8473338
OpenAlexW3200667898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.