Evidence map›Paper›PMID 34578416›Full record

ArticleViruses2021

In Vitro Model Systems of Coxsackievirus B3-Induced Myocarditis: Comparison of Commonly Used Cell Lines and Characterization of CVB3-Infected iCell

Lisa Kraft, Martina Sauter, Guiscard Seebohm, Karin Klingel

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Alkaloids as potential antivirals. A comprehensive review.Natural products and bioprospecting · 2023
    Review
  5. Necroptosis and Viral Myocarditis: Tumor Necrosis FactorFrontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lisa KraftCardiopathology, Institute for Pathology and Neuropathology, University Hospital Tübingen, Liebermeisterstraße 8, D-72076 Tübingen, Germany.
Martina SauterCardiopathology, Institute for Pathology and Neuropathology, University Hospital Tübingen, Liebermeisterstraße 8, D-72076 Tübingen, Germany.
Guiscard SeebohmDepartment of Cardiovascular Medicine, Institute for Genetics of Heart Diseases (IfGH), University Hospital Münster, Robert-Koch-Str. 45, D-48149 Münster, Germany.
Karin KlingelCardiopathology, Institute for Pathology and Neuropathology, University Hospital Tübingen, Liebermeisterstraße 8, D-72076 Tübingen, Germany.ORCID 0000-0003-0203-2498
University Hospital Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coxsackievirus B3 (CVB3) belongs to the enteroviruses, which are a well-known cause of acute and chronic myocarditis, primarily infecting cardiac myocytes. As primary human cardiomyocytes are difficult to obtain, viral myocarditis is quite frequently studied in vitro in different non-cardiac and cardiac-like cell lines. Recently, cardiomyocytes that have been differentiated from human-induced pluripotent stem cells have been described as a new model system to study CVB3 infection. Here, we compared iCell

Indexed as

Models, BiologicalAnimalsCapsid ProteinsCell DeathCell LineChlorocebus aethiopsEnterovirus B, HumanHeLa CellsHumansIn Vitro TechniquesMiceMyocarditisMyocytes, CardiacPeptide HydrolasesReceptor-Interacting Protein Serine-Threonine KinasesVero CellsCapsid ProteinsPeptide HydrolasesReceptor-Interacting Protein Serine-Threonine KinasesRIPK1 protein, humanRIPK3 protein, humanCardiomyocytescoxsackievirus B3iCell®myocarditisnecroptosisRIPK1RIPK3

Identifiers

PMID34578416
PMCPMC8472939
OpenAlexW3200907418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.