Evidence map›Paper›PMID 34578370›Full record

ArticleViruses2021

Different Profiles of Cytokines, Chemokines and Coagulation Mediators Associated with Severity in Brazilian Patients Infected with Dengue Virus.

Victor Edgar Fiestas Solórzano, Nieli Rodrigues da Costa Faria, Caroline Fernandes Dos Santos, Gladys Corrêa, Márcio da Costa Cipitelli, Marcos Dornelas Ribeiro, Luiz José de Souza, Paulo Vieira Damasco, Rivaldo Venâncio da Cunha, Flavia Barreto Dos Santos and 2 more

Abstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Neutrophil Extracellular Traps in Viral Infections.Pathogens (Basel, Switzerland) · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Victor Edgar Fiestas SolórzanoViral Immunology Laboratory, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro 21040-360, Brazil.
Nieli Rodrigues da Costa FariaViral Immunology Laboratory, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro 21040-360, Brazil.
Caroline Fernandes Dos SantosViral Immunology Laboratory, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro 21040-360, Brazil.
Gladys CorrêaViral Immunology Laboratory, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro 21040-360, Brazil.
Márcio da Costa CipitelliMolecular Biology Laboratory, Instituto de Biologia do Exército, Rio de Janeiro 20911-270, Brazil.
Marcos Dornelas RibeiroMolecular Biology Laboratory, Instituto de Biologia do Exército, Rio de Janeiro 20911-270, Brazil.
Luiz José de SouzaCentro de Referência de Doenças Imuno-Infecciosas, Campos dos Goytacazes 28025-496, Brazil.
Paulo Vieira DamascoRede Casa Hospital Rio Laranjeiras, Rio de Janeiro 22240-000, Brazil.
Rivaldo Venâncio da CunhaFaculdade de Medicina, Universidade Federal de Mato Grosso do Sul, Campo Grande 79070-900, Brazil.
Flavia Barreto Dos SantosViral Immunology Laboratory, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro 21040-360, Brazil.ORCID 0000-0002-1309-5366
Luzia Maria de Oliveira PintoViral Immunology Laboratory, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro 21040-360, Brazil.
Elzinandes Leal de AzeredoViral Immunology Laboratory, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro 21040-360, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The incidence of dengue in Latin America has increased dramatically during the last decade. Understanding the pathogenic mechanisms in dengue is crucial for the identification of biomarkers for the triage of patients. We aimed to characterize the profile of cytokines (IFN-γ, TNF-α, IL-1β, IL-6, IL-18 and IL-10), chemokines (CXCL8/IL-8, CCL2/MCP-1 and CXCL10/IP-10) and coagulation mediators (Fibrinogen, D-dimer, Tissue factor-TF, Tissue factor pathway inhibitor-TFPI and Thrombomodulin) during the dengue-4 epidemic in Brazil. Laboratory-confirmed dengue cases had higher levels of TNF-α (

Indexed as

Severity of Illness IndexAdultBiomarkersBlood Coagulation FactorsBrazilChemokinesCytokinesDengueDengue VirusFemaleHumansInflammationMaleMiddle AgedBiomarkersBlood Coagulation FactorsChemokinesCytokinesbiomarkersBrazildengueprincipal component analysis

Identifiers

PMID34578370
PMCPMC8473164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.