Evidence map›Paper›PMID 34578369›Full record

ReviewViruses2021

RNA Structures and Their Role in Selective Genome Packaging.

Liqing Ye, Uddhav B Ambi, Marco Olguin-Nava, Anne-Sophie Gribling-Burrer, Shazeb Ahmad, Patrick Bohn, Melanie M Weber, Redmond P Smyth

Abstract readReview
In one paragraph

Review in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. In vivo secondary structural analysis of Influenza A virus genomic RNA.Cellular and molecular life sciences : CMLS · 2023
    Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liqing YeGenome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, Germany.ORCID 0000-0002-0228-3900
Uddhav B AmbiGenome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, Germany.
Marco Olguin-NavaGenome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, Germany.
Anne-Sophie Gribling-BurrerGenome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, Germany.
Shazeb AhmadGenome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, Germany.
Patrick BohnGenome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, Germany.
Melanie M WeberGenome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, Germany.
Redmond P SmythGenome Architecture and Evolution of RNA Viruses, Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, 97080 Würzburg, Germany.ORCID 0000-0002-1580-0671

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To generate infectious viral particles, viruses must specifically select their genomic RNA from milieu that contains a complex mixture of cellular or non-genomic viral RNAs. In this review, we focus on the role of viral encoded RNA structures in genome packaging. We first discuss how packaging signals are constructed from local and long-range base pairings within viral genomes, as well as inter-molecular interactions between viral and host RNAs. Then, how genome packaging is regulated by the biophysical properties of RNA. Finally, we examine the impact of RNA packaging signals on viral evolution.

Indexed as

Genome, ViralEvolution, MolecularHumansNucleic Acid ConformationRNA, ViralRNA VirusesVirus AssemblyRNA, Viralevolutiongenome packagingRNARNA structureRNA virusviral assembly

Identifiers

PMID34578369
PMCPMC8472981

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.