Evidence map›Paper›PMID 34578366›Full record

ArticleViruses2021

Bacteriophage Rescue Therapy of a Vancomycin-Resistant

Kevin Paul, Maya Merabishvili, Ronen Hazan, Martin Christner, Uta Herden, Daniel Gelman, Leron Khalifa, Ortal Yerushalmy, Shunit Coppenhagen-Glazer, Theresa Harbauer and 9 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 67 citations in OpenAlex.

  1. Pharmacology of Bacteriophage Therapy in Children: A Re-Emerging Paradigm in Antibacterial Therapy.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Characterization ofPHAGE (New Rochelle, N.Y.) · 2026
    Article
  6. Isolation and characterization of broad-rangeMicrobiology (Reading, England) · 2026
    Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Journal of bacteriology · 2025
    Article
  12. Review
  13. Article
  14. Spread of the novel vancomycin-resistantEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Observational
  15. Review
  16. Article
  17. Review
  18. Bibliometric analysis of hotspots inFrontiers in microbiology · 2025
    Article
  19. Harnessing phages to tackle antimicrobial resistance: a Saudi Arabian perspective.Frontiers in cellular and infection microbiology · 2025
    Review
  20. Phage diversity in One Health.Essays in biochemistry · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 4 countries.

Kevin PaulDepartment of Pediatrics, Kinder-UKE, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-0998-4881
Maya MerabishviliBurn Centre, Laboratory for Molecular and Cellular Technology (LabMCT), Queen Astrid Military Hospital, B-1120 Brussels, Belgium.ORCID 0000-0002-2566-0772
Ronen HazanInstitute of Dental Sciences, School of Dentistry, Hebrew University of Jerusalem, Jerusalem 9112001, Israel.ORCID 0000-0001-9967-730X
Martin ChristnerInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Uta HerdenDepartment of Visceral Transplantation, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Daniel GelmanInstitute of Dental Sciences, School of Dentistry, Hebrew University of Jerusalem, Jerusalem 9112001, Israel.
Leron KhalifaInstitute of Dental Sciences, School of Dentistry, Hebrew University of Jerusalem, Jerusalem 9112001, Israel.
Ortal YerushalmyInstitute of Dental Sciences, School of Dentistry, Hebrew University of Jerusalem, Jerusalem 9112001, Israel.ORCID 0000-0002-8994-3114
Shunit Coppenhagen-GlazerInstitute of Dental Sciences, School of Dentistry, Hebrew University of Jerusalem, Jerusalem 9112001, Israel.
Theresa HarbauerDepartment of Pediatrics, Kinder-UKE, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Sebastian Schulz-JürgensenDepartment of Pediatrics, Kinder-UKE, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Holger RohdeInstitute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0001-8587-4433
Lutz FischerDepartment of Visceral Transplantation, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Saima AslamCenter for Innovative Phage Applications and Therapeutics, Division of Infectious Diseases and Global Public Health, University of California, San Diego, CA 92093, USA.
Christine RohdeLeibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures GmbH, 38124 Braunschweig, Germany.
Ran Nir-PazDepartment of Clinical Microbiology and Infectious Disease, Hadassah University Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112001, Israel.
Jean-Paul PirnayBurn Centre, Laboratory for Molecular and Cellular Technology (LabMCT), Queen Astrid Military Hospital, B-1120 Brussels, Belgium.ORCID 0000-0002-6863-5219
Dominique SingerDepartment of Pediatrics, Kinder-UKE, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Ania Carolina MuntauDepartment of Pediatrics, Kinder-UKE, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-2900-8378
Universität Hamburg · DEHebrew University of Jerusalem · ILQueen Astrid Military Hospital · BELeibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures · DEUniversity of California San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phage therapy is an experimental therapeutic approach used to target multidrug-resistant bacterial infections. A lack of reliable data with regard to its efficacy and regulatory hurdles hinders a broad application. Here we report, for the first time, a case of vancomycin-resistant

Indexed as

Anti-Bacterial AgentsCross InfectionDrug Resistance, Multiple, BacterialEnterococcus faeciumFemaleGenome, BacterialGram-Positive Bacterial InfectionsHumansInfantLiver TransplantationMicrobial Sensitivity TestsPhage TherapyTreatment OutcomeVancomycinVancomycin-Resistant EnterococciWhole Genome SequencingAnti-Bacterial AgentsVancomycinbacteriophagebiliary atresiacritical careEnterococcus faeciumliver transplantationmulti-drug resistancepediatricvancomycin

Identifiers

PMID34578366
PMCPMC8472888
OpenAlexW3197851034

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.